HOME >> BIOLOGY >> NEWS
UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies

Irvine, Calif., Sept. 23, 2004 -- In what may be a first step toward expanding the arsenal against HIV, UC Irvine researchers have successfully targeted an HIV protein that has eluded existing therapies.

Researchers targeted Nef, a protein responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was targeted with small molecules synthesized by the researchers molecules that disrupted Nef's interaction with other proteins.

The technique used for identifying the synthetic molecules also may lead to new drug therapies with improved treatment options.

The researchers used a scientific technique called "phage display," which is used to identify small molecule inhibitors that can disrupt interactions between proteins. According to Gregory Weiss, lead researcher and assistant professor in the Department of Chemistry, his research team attached the Nef protein to the surface of a harmless virus, then created synthetic molecules that could target and dislodge the protein.

This is the first time phage display has been used to identify molecules that disrupt protein-protein interactions. (For more detail, see "About the Research.")

While the method was successful, Weiss said the molecules identified proved toxic to cells. He is now seeking to develop less toxic compounds that will have high potencies against Nef without causing collateral damage. A key benefit of this achievement, he added, would be the development of therapies using smaller molecules, which can often be used in oral medications. Therapies that rely on larger molecules are used in medications injected by needle.

"By proving small molecules can be effective for targeting Nef, we've shown how researchers can expand the fight against AIDS," said Weiss.

The researchers reported their findings last week in the online edition of the Proceedings of the National Academy of Science. The print version of the research pap
'"/>

Contact: Iqbal Pittalwala
iqbal@uci.edu
949-824-3969
University of California - Irvine
24-Sep-2004


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. Alaska scientists find Arctic tundra yields surprising carbon loss
5. UAF scientists discover new marine habitat in Alaska
6. Information system to help scientists analyze mechanisms of social behavior
7. Zoonotic diseases - European scientists unite to fight diseases
8. Israeli scientists reveal the plan of a key cellular machine
9. Study by Israeli scientists provides insight on DNA code
10. Computer scientists at UH developing nurturing computers
11. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2019)... ... May 09, 2019 , ... Akadeum ... of products based on its microbubble technology. Unlike magnetic-based products, microbubbles use buoyancy ... surface. Feedback from customers who participated in an early access program has been ...
(Date:5/8/2019)... ... May 08, 2019 , ... RG+A, Inc., a leading ... Mann has agreed to serve as Chief Executive Officer and pharmaceutical leader Dr. ... immediately. They will join Chairman and Founder Roger Green to create a three-person ...
(Date:5/8/2019)... ... May 08, 2019 , ... Great Point Partners (“GPP”) ... of unified eClinical solutions and services that are used to enhance the efficiency ... a leading e-clinical technology company that focuses on Electronic Data Capture (“EDC”), Data ...
Breaking Biology News(10 mins):
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer ... bench plant expansion to increase production of methylene malonate monomers and oligomers. , ... of Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. ...
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny for ... approximately two months. After a series of diagnostics, an MRI was performed which ... Alison, researched the injury and found that VetStem Regenerative Cell Therapy may ...
(Date:4/4/2019)... ... 2019 , ... Biomeme, Inc. , a leading manufacturer ... solution for performing PCR, RT-PCR, qPCR, and Isothermal tests called Franklin ™. ... an English chemist and X-ray crystallographer who made significant contributions to the understanding ...
(Date:3/27/2019)... N.Y. (PRWEB) , ... March 27, 2019 , ... Lachman ... #60 at the Clayton Hotel Burlington Road, Dublin, Ireland. The executive team on site ... and Pharma 4.0, two key tracks on the agenda this year. , Executives from ...
Breaking Biology Technology:
Cached News: