HOME >> BIOLOGY >> NEWS
UCLA neuroscientists discovery distinct molecular key to overcoming fear

In a discovery with implications for treatment of anxiety disorders, UCLA Neuropsychiatric Institute investigators have identified a distinct molecular process in the brain involved in overcoming fear. The findings will be published in the Oct. 15 edition of the Journal of Neuroscience.

The study of how mice acquire, express and extinguish conditional fear shows for the first time that L-type voltage-gated calcium channels (LVGCCs) -- one of hundreds of varieties of electrical switches found in brain cells -- are required to overcome fear but play no role in becoming fearful or expressing fear. The findings suggest that it may be possible to identify the cells, synapses and molecular pathways specific to extinguishing fear, and to the treatment of human anxiety disorders.

"Brain plasticity, or the ability of the central nervous system to modify cellular connections, has long been recognized as a key component to learning and memory," said Dr. Mark Barad, the UCLA Neuropsychiatric Institute's Tennenbaum Family Center faculty scholar and an assistant professor in-residence of psychiatry at the David Geffen School of Medicine at UCLA. "The discovery of a distinct molecular process in overcoming fear bodes well for development of new drugs that can make psychotherapy, or talk therapy, easier and more effective in treating anxiety disorders. More broadly, the findings also suggest that distinct molecular processes may be involved in the expression and treatment of other psychiatric disorders."

Both the acquisition and extinction of conditional fear are forms of active learning. The acquisition of conditional fear requires a unique pairing of an initially neutral conditional stimulus with an aversive unconditional stimulus. In this research, the conditional stimulus was a tone and the unconditional stimulus was a mild foot shock.

Although extinction, the reduction of conditional responding after repeated exposures to the conditional stimulu
'"/>

Contact: Dan Page
dpage@support.ucla.edu
310-794-2265
University of California - Los Angeles
15-Oct-2002


Page: 1 2

Related biology news :

1. UCLA neuroscientists first to show that adult brains turn back developmental clock to repair damage
2. USF neuroscientists study potential of cord blood cells to rescue aging brain
3. Vanderbilt neuroscientists identify oops center in the brain
4. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
5. New OHSU lab will speed drug discovery process
6. New discovery may help transplants survive
7. Genetic discovery could dramatically reduce need for liver transplants in children
8. Plant gene discovery could enhance plant growth, reduce fertilizer needs and phosphate pollution
9. Major scientific discovery in cancer research to be honored
10. New discovery could provide tool to detect whether a cancer will develop and spread
11. UNC research accelerates discovery of novel gene function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 20, 2020 , ... ... Movahhed , a Clinical Operations executive with expertise in clinical trial planning and ... firm as an Expert Consultant. Throughout his career, Mr. Movahhed has helped design ...
(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... to participate in the prestigious National STEM Scholar Program, a unique professional development ... building, and project support for middle school science teachers nationwide. , Created in ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July 30, 2020 , ... ... maturing prescription digital therapeutics product portfolio with a near term focus on Type ... biotech and pharma commercialization experience across multiple therapeutic areas and classes. As Chief ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... 2020 , ... Medial EarlySign , a leader in ... high-burden diseases, and Centric Consulting, a business and technology consulting firm, today announced ... in order to identify and prioritize patients for care. , Combining Centric’s management ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Institute of Technology (MIT) has expanded the company’s exclusive license to include ... into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem cell ... million stem cells. Depending on the patient's condition, treatment may be offered IV, intrathecal ... having some form of Alzheimers dementia, and the incidence continues to increase as individuals ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing System (TIPS), ... membership, recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor ... seating, cafeteria tables, book trucks and carts at discounted pricing without the delay ...
Breaking Biology Technology:
Cached News: