HOME >> BIOLOGY >> NEWS
UCLA neuroscientists first to show that adult brains turn back developmental clock to repair damage

A new study by UCLA neuroscientists shows for the first time that a unique pattern of cellular activity found in early brain development also triggers repairs to damaged adult brains. The findings, appearing in the July 15 edition of the peer-reviewed Journal of Neuroscience, hold implications for treating brain damage caused by stroke and other disorders.

Researchers in the Department of Neurology and Brain Research Institute at UCLA used rat models to show how cells in brains damaged with stroke-like lesions, caused by interruption of blood flow, develop slow synchronous activity. This activity triggers cells to sprout new connections into areas of the brain disconnected by the lesion.

"Our research shows for the first time that this activity works to trigger repairs in adult brains," said Dr. Marie-Francoise Chesselet, professor of neurology at the David Geffen School of Medicine at UCLA and study co-author. "Previously this activity has been identified as a key component of brain development."

Scientists and clinicians had recognized this pattern of activity for many years after brain injury in humans, but its function remained unknown. This new research suggests that these cellular rhythms may be signaling a repair process in the human brain after injury.

"On its own, a damaged brain has a limited ability to repair itself. Recovery is partial," said Dr. S. Thomas Carmichael, assistant professor of neurology at UCLA and study co-author. "A better understanding of how the brain recovers from injury will allow us to manipulate the repair process and to maximize recovery from brain damage caused by stroke and other disorders."

The researchers made their discovery using a model of brain injury that allowed them to isolate signals specific to the sprouting of new connections from other changes that occur because of damage. They then measured the frequency, power and synchroneity of brain activity in a model that induced sprouti
'"/>

Contact: Dan Page
dpage@support.ucla.edu
310-794-2264
University of California - Los Angeles
16-Jul-2002


Page: 1 2

Related biology news :

1. UCLA neuroscientists discovery distinct molecular key to overcoming fear
2. USF neuroscientists study potential of cord blood cells to rescue aging brain
3. Vanderbilt neuroscientists identify oops center in the brain
4. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
5. Newly identified master gene key in babys first breath
6. The book opens on the first tree genome
7. DuPont developing new protective suits for military, first responders
8. Joslin Diabetes Center adds first affiliate in California at Irvine Medical Center
9. Maine-based biophysics institute gets funding for first US-based 4Pi nanoscale microscope
10. Veterinarians discover first known case of canine distemper in a wild tiger
11. Study reveals first genetic step necessary for prostate cancer growth

Post Your Comments:
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ... "India Sensors Market Forecast and Opportunities 2020" ... market is projected to grow at a CAGR ... automotive, industrial and healthcare sectors are the key ... addition, adoption of MEMS technology in sensors is ...
(Date:3/20/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces its biometric ... the products featured in 2015 "I Want That" International ... EST on the DIY Network.   DIY,s ... , site of the 2015 International CES for ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
(Date:3/31/2015)... , March 31, 2015  The Myeloma Crowd Research ... selection of ten proposals that will now be ... first patient-led, scientifically validated funding initiative uncovering solutions ... 2 of the MCRI included preliminary vetting by ... a large number of innovative projects focusing on ...
(Date:3/31/2015)... 2015 Diasome Pharmaceuticals, Inc. ( http://www.diasome.com ... that a United States patent has recently been allowed ... , Entitled “Lipid Construct for Delivery of Insulin ... claims related to the use of Diasome’s proprietary Hepatocyte ... insulin to more effectively reach the liver’s metabolic cells, ...
(Date:3/30/2015)... 2015  Heidrick & Struggles (Nasdaq: HSII ), the ... and culture shaping worldwide, today  announced that ... its global Healthcare and Life Sciences practice. As ... will lead a team of more than 80 partners, principals ... and Asia serving clients in the ...
(Date:3/30/2015)... OTTAWA , March 30, 2015 /CNW/ - A ... today on the salaries and demographic profiles of new ... "Opening the Door – Building Careers for New Grads ... Canada,s Research-Based Pharmaceutical Companies (Rx&D) and features ... federal Career Focus wage subsidy program from 2013 to ...
Breaking Biology Technology:Myeloma Crowd Research Initiative Selects 10 High-Risk Multiple Myeloma Proposals For Further Review 2Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2Heidrick & Struggles Strengthens Leadership of Healthcare - Life Sciences Practice 2New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 2New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 3New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 4
Cached News: