HOME >> BIOLOGY >> NEWS
UCLA physicists create nanoscale sensor

UCLA physicists have created a first-of-its-kind nanoscale sensor using a single molecule less than 20 nanometers long -- more than 1,000 times smaller than the thickness of a human hair -- the team reports in the June 24 issue of the Proceedings of the National Academy of Sciences.

The nano molecular sensor could help with early diagnosis of genetic diseases, and have numerous other applications for medicine, biotechnology and other fields, said Giovanni Zocchi, assistant professor of physics at UCLA, member of the California NanoSystems Institute and leader of the research team.

"This nanoscale single-molecule method could lead to significant improvements in early diagnosis of genetic diseases, including the growing number of cancer forms for which genetic markers are known," Zocchi said. "The largest potential applications for this sensor may be in the drug discovery process, where the possibility of quickly gauging the gene expression response of cells to prospective drugs is crucial."

The research is federally funded by the National Science Foundation.

Zocchi's nanoscale sensor uses a single molecule to recognize the presence of a specific short sequence in a mixture of DNA or RNA molecules -- which he equates to finding a needle in a haystack.

"Traditional assays use an averaged procedure that detects a minimum amount of molecules, but our method can detect a single one," Zocchi said. "When a target molecule binds to the probe in the sensor, the probe molecule changes shape, and in its new conformation, pulls on the sensor. It is remarkable that a single molecule can actually move the sensor, because the relative sizes are comparable to one person trying to move a mountain, but mass is of no consequence at these miniscule scales."

The motion of the sensor is detected by an optical technique called "evanescent wave scattering," which analyzes light that leaks out behind a reflecting mirror. This evanescent wave ca
'"/>

Contact: Stuart Wolpert
stuartw@college.ucla.edu
310-206-0511
University of California - Los Angeles
19-Jun-2003


Page: 1 2 3

Related biology news :

1. Rice, Brookhaven physicists decode initial stage of cell fusion
2. UB biophysicists discover high-speed motility in cells in response to voltage changes
3. Yale physicists first to create a squeezed state of atoms, which could lead to improved sensitivity ofnavigation systems used on planes and ships
4. CWRU physicists invent "supershielding" for MRI devices
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Florida Tech earns $50,000 grant to create coral database
7. New sign language suggests children create languages fundamentals through learning
8. Ancient life form may help create newest technologies
9. UAB creates the first Internet server to search for genetic diversity
10. AACR applauds FDA decision to create new office of oncology drug products
11. ORNL nanoprobe creates world of new possibilities

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2020)... HANOVER, Md. and LEXINGTON, Mass. (PRWEB) , ... May 06, 2020 ... ... Hemanext Inc. , a privately held medical technology company dedicated to improving the ... to announce a new partnership that will help SCDAA deliver on its mission and ...
(Date:5/1/2020)... (PRWEB) , ... April 30, 2020 , ... ... emerging infectious diseases, announced today that it had been awarded a contract from ... the Assistant Secretary for Preparedness and Response at the U.S. Department of Health ...
(Date:4/30/2020)... ... 2020 , ... At the start of 2020 ILC ... a wide range of industries including pharmaceutical and biopharmaceutical manufacturing, healthcare, food and ... decade, it was clear to company leadership that they would have to adapt ...
Breaking Biology News(10 mins):
(Date:5/28/2020)... SPRING, Md. (PRWEB) , ... May 28, 2020 , ... ... distinguished biometrics and security leaders as the 2020 winners of the Women in ... co-presented with sponsors IDEMIA , Biometric Update and the SIA ...
(Date:5/21/2020)... ... ... Eaton Square is pleased to announce its growth on the East Coast ... technology-focused strategy and M&A advisory firm. , This is an important step for Eaton ... Pacific healthcare innovators with capital and investors. , Popper and Company, founded in 2003 ...
(Date:5/15/2020)... ... May 14, 2020 , ... This new service offers clients ... most pressing questions answered quickly as the need arises. Lachman’s OnCall SMEs have extensive ... at affordable rates. , Lachman OnCall™ SMEs are available normal business hours Monday ...
(Date:5/14/2020)... ... May 13, 2020 , ... ... Future Lab: Optimizing Workflows in the Life Science Lab . The comprehensive ... their lab, from water purification and liquid handling to contamination control. , The ...
Breaking Biology Technology:
Cached News: