HOME >> BIOLOGY >> NEWS
UCLA researchers recreate patterns formed by mammalian cells

In early development, how do cells know to put the right spacing between ribs, fingers and toes? How do they communicate with each other to form symmetrical and repeated patterns such as zebra stripes or leopard spots?

For the first time, UCLA researchers have recreated the ability of mammalian cells to self-organize, forming evenly spaced patterns in a test tube. Published in the June 22, 2004 issue of the Proceedings of the National Academy of Sciences, the findings may help improve methods for regenerating tissue, controlling birth defects and developing new treatments for specific diseases.

"Just as a marching band needs direction from a conductor to line up in formation on a football field, cells also need guidance to form patterns -- but until now we didn't know how they were communicating or receiving direction," said Alan Garfinkel, Ph.D., first author and professor of physiology and cardiology at the David Geffen School of Medicine at UCLA.

"Previously it was a bit magical how cells knew exactly how far apart to space ribs or tiger stripes," said Dr. Linda L. Demer, senior investigator, Guthman Professor of Medicine and Physiology, and vice chair for cardiovascular and vascular medicine at the David Geffen School of Medicine at UCLA. "We now know that it's orchestrated by specific proteins produced by cells that disperse at different rates and interfere with one another. These interactions can be described in mathematical formulas dictating how cells organize into specific, evenly spaced patterns."

Demer notes that similar mechanisms may explain how an embryo creates structures in evenly spaced patterns in early development or how certain diseases may trigger cells to create lesions in specific patterns.

Researchers grew stem cells from adult bovine arteries and found that they produce intricate, lace-like patterns in culture dishes. Such patterns are known to be created in nature by a process called reaction-
'"/>

Contact: Rachel Champeau
rchampeau@support.ucla.edu
310-794-0777
University of California - Los Angeles
14-Jun-2004


Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
Breaking Biology Technology:
Cached News: