HOME >> BIOLOGY >> NEWS
UCLA researchers recreate patterns formed by mammalian cells

In early development, how do cells know to put the right spacing between ribs, fingers and toes? How do they communicate with each other to form symmetrical and repeated patterns such as zebra stripes or leopard spots?

For the first time, UCLA researchers have recreated the ability of mammalian cells to self-organize, forming evenly spaced patterns in a test tube. Published in the June 22, 2004 issue of the Proceedings of the National Academy of Sciences, the findings may help improve methods for regenerating tissue, controlling birth defects and developing new treatments for specific diseases.

"Just as a marching band needs direction from a conductor to line up in formation on a football field, cells also need guidance to form patterns -- but until now we didn't know how they were communicating or receiving direction," said Alan Garfinkel, Ph.D., first author and professor of physiology and cardiology at the David Geffen School of Medicine at UCLA.

"Previously it was a bit magical how cells knew exactly how far apart to space ribs or tiger stripes," said Dr. Linda L. Demer, senior investigator, Guthman Professor of Medicine and Physiology, and vice chair for cardiovascular and vascular medicine at the David Geffen School of Medicine at UCLA. "We now know that it's orchestrated by specific proteins produced by cells that disperse at different rates and interfere with one another. These interactions can be described in mathematical formulas dictating how cells organize into specific, evenly spaced patterns."

Demer notes that similar mechanisms may explain how an embryo creates structures in evenly spaced patterns in early development or how certain diseases may trigger cells to create lesions in specific patterns.

Researchers grew stem cells from adult bovine arteries and found that they produce intricate, lace-like patterns in culture dishes. Such patterns are known to be created in nature by a process called reaction-
'"/>

Contact: Rachel Champeau
rchampeau@support.ucla.edu
310-794-0777
University of California - Los Angeles
14-Jun-2004


Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCLA researchers recreate patterns formed mammalian cells

(Date:10/17/2014)... is critical and pertinent for practicing physicians and clinicians ... epidemic. The Journal, Disaster Medicine and Public Health ... and Public Health, to surround the public, medical professionals ... moment. , On October 17, the journal published ... primer was prepared by Dr. Eric Toner, internist and ...
(Date:10/16/2014)... the human body. Battles are won, lost or ... this stalemate—known as tumor dormancy—can last up to ... that is poorly understood. , A new ... Torquato, a Professor of Chemistry at Princeton University, ... and the switch to a malignant state. Published ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market ... analysis and forecast of revenue. The electronic medical record market ... million by 2018, at a CAGR of 9.4% from 2013 ... Electronic Medical Record (EMR) market, to get an idea of ... the segmentation of the market in the same region, and ...
(Date:10/18/2014)... 18, 2014 The “Global Diagnostic ... Monitor), by End-user (Hospitals, Home/Ambulatory, Research Center, Physician ... 12) -Global Forecast to 2020” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
(Date:10/17/2014)... October 17, 2014 For the ... employers, as published in today’s print issue of ... annual Top Employers Survey polled employees in the ... 20 best employers. Rankings were determined based ... to rate their companies on 23 characteristics, including ...
(Date:10/17/2014)... Europe Fuel Additives Market report defines and segments the ... of revenue. , Browse through the TOC of the ... of the in-depth analysis provided. This also provides a ... market, and is supported by various tables and figures. ... chemicals that are used to enhance the properties of ...
Breaking Biology Technology:The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 2The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: