UCLA scientists image how Parkinsons genes misfi...( UCLA scientists have developed a fast n...)

The new findings are reported in the June edition of Genome Research.

Last year, UCLA pharmacologist Desmond Smith developed a new method to rapidly track how genes express proteins in the human brain. Called voxelation, the approach involves cutting the brain into cubes, then using DNA chip technology and math to reconstruct gene expression patterns in three-dimensional images.

This time, Smith used voxelation to compare gene expression in the brains of mice. Half of the mice received drugs to induce Parkinsons disease. The UCLA team analyzed the brain cubes with DNA chips to track the expression of 9,000 genes simultaneously. They then combined the 9,000 resulting images to visualize how the genes construct the brain.

When they compared the colored brain images of the healthy and diseased mice, Smith and his colleagues discovered that the brains of the mice with Parkinsons disease showed an abnormal shift in gene activity. The patterns of gene expression had moved and were not located in the brain where they should have been.

This approach identifies which genes play a role in abnormal brain function and where they are located, said Smith, UCLA assistant professor of molecular and medical pharmacology. We can use this information to narrow down the brain regions linked to genetic disorders and pinpoint the genes responsible for causing them.

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Contact: Elaine Schmidt
elaines@support.ucla
310-794-2272
University of California - Los Angeles
29-May-2002