HOME >> BIOLOGY >> NEWS
UCSD biologists discover new class of genes responsible for embryonic development

Biologists at the University of California, San Diego have discovered in the roundworm C. elegans a new class of genes necessary for the normal development of the earliest stages of embryonic development in animals.

In the May issue of the journal Developmental Biology, the UCSD researchers report the discovery of a new class of genes that regulates the asymmetric division of the first cell in the developing embryo into an unequal sized pair of cells.

"The actual mechanisms by which this happens are not well understood," says Raffi V. Aroian, an assistant professor of biology at UCSD who headed the research. "By understanding more about the genes that regulate this process, we can provide more information about one of the key questions in developmental biology-how complex organisms such as humans develop from a single-celled embryo."

In normal embryos, the larger of these cells develops into the outer layers of an organism, such as its skin and nervous system, while the smaller of the two cells develops into the inner portions, such as its muscle, gut and reproductive organs. When one of the genes in this new class is defective, however, the absence of differences between the two cells prevents the differentiation necessary for development.

"If the asymmetrical division is screwed up, the embryo is never going to make it," says Akiko Tagawa, a graduate student and the lead author of the paper, which also includes Chad A. Rappleye, another graduate student working in Aroian's laboratory. "It quickly dies."

In addition, the cells containing these mutant genes are vulnerable to bursting and shriveling. This is due to the inability of the defective embryo's cell membranes to maintain the cell's osmotic pressure, which can produce an undesirable flood of fluids into or out of the cells.

The UCSD scientists have dubbed their new class pod genes-for polarity and osmotic defective genes-because mutations in them resu
'"/>

Contact: Kim McDonald
kimmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
30-Apr-2001


Page: 1 2

Related biology news :

1. Tracing genes, biologists show lizard migration is traced to Florida
2. UCLA molecular biologists uproot the tree of life
3. UCSD biologists develop super-endurance strain of mice
4. Springtime blooms seen earlier now than in the past, say Boston University biologists
5. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins
6. U of T microbiologists achieve results with pattern recognition software
7. Parting genomes: UA biologists discover seeds of speciation
8. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
9. Plant biologists Delmer, Quail, Bennetzen elected to National Academy of Sciences
10. New York microbiologists awarded research grants in antibiotic resistance and lyme disease
11. Purdue biologists expose the inner workings of viral machine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/15/2016)... 2016 --> --> ... Market Research "Digital Door Lock Systems Market - Global Industry ... the global digital door lock systems market in terms of ... is forecast to grow at a CAGR of 31.8% during ... medium enterprises (MSMEs) across the world and high industrial activity ...
(Date:3/11/2016)... --> --> ... Recognition Market by Technology (Pattern Recognition), by Component (Hardware, ... Type (On-Premises and Cloud), by Industry Vertical and by ... the global market is expected to grow from USD ... 2020, at a CAGR of 19.1%. , ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... made significant investments in recruiting top industry experts, and expanding its LATAM network ... provides industry-leading tools for clients to manage their clinical trial projects. , The ...
(Date:4/27/2016)... , ... April 27, 2016 , ... The Pittcon Organizing ... 2019. Chuck has been a volunteer member of Committee since 1987. Since then, ... board of directors and treasurer and was chairman for both the program and exposition ...
(Date:4/27/2016)... Virgin Islands (PRWEB) , ... April 27, 2016 ... ... Company Ltd. (d/b/a Biohaven) is pleased to announce the appointment of John Tilton as ... was an Executive Director and one of the founding commercial leaders responsible for ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group CEO ... is the founder of GSCG affiliate Kimera Labs in Miami. , In 2004, Ross ... stem cell transplantation for hematologic disorders and the suppression of graft vs. host disease ...
Breaking Biology Technology:
Cached News: