HOME >> BIOLOGY >> NEWS
UCSD biologists discover new class of genes responsible for embryonic development

Biologists at the University of California, San Diego have discovered in the roundworm C. elegans a new class of genes necessary for the normal development of the earliest stages of embryonic development in animals.

In the May issue of the journal Developmental Biology, the UCSD researchers report the discovery of a new class of genes that regulates the asymmetric division of the first cell in the developing embryo into an unequal sized pair of cells.

"The actual mechanisms by which this happens are not well understood," says Raffi V. Aroian, an assistant professor of biology at UCSD who headed the research. "By understanding more about the genes that regulate this process, we can provide more information about one of the key questions in developmental biology-how complex organisms such as humans develop from a single-celled embryo."

In normal embryos, the larger of these cells develops into the outer layers of an organism, such as its skin and nervous system, while the smaller of the two cells develops into the inner portions, such as its muscle, gut and reproductive organs. When one of the genes in this new class is defective, however, the absence of differences between the two cells prevents the differentiation necessary for development.

"If the asymmetrical division is screwed up, the embryo is never going to make it," says Akiko Tagawa, a graduate student and the lead author of the paper, which also includes Chad A. Rappleye, another graduate student working in Aroian's laboratory. "It quickly dies."

In addition, the cells containing these mutant genes are vulnerable to bursting and shriveling. This is due to the inability of the defective embryo's cell membranes to maintain the cell's osmotic pressure, which can produce an undesirable flood of fluids into or out of the cells.

The UCSD scientists have dubbed their new class pod genes-for polarity and osmotic defective genes-because mutations in them resu
'"/>

Contact: Kim McDonald
kimmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
30-Apr-2001


Page: 1 2

Related biology news :

1. Tracing genes, biologists show lizard migration is traced to Florida
2. UCLA molecular biologists uproot the tree of life
3. UCSD biologists develop super-endurance strain of mice
4. Springtime blooms seen earlier now than in the past, say Boston University biologists
5. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins
6. U of T microbiologists achieve results with pattern recognition software
7. Parting genomes: UA biologists discover seeds of speciation
8. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
9. Plant biologists Delmer, Quail, Bennetzen elected to National Academy of Sciences
10. New York microbiologists awarded research grants in antibiotic resistance and lyme disease
11. Purdue biologists expose the inner workings of viral machine

Post Your Comments:
(Date:10/16/2014)... Syncytial Virus causes severe respiratory tract infections and ... year. Scientists at VIB and Ghent University have ... counteract this common virus infection. , Xavier ... that paves the way for the development of ... virus that causes suffering in numerous small children ...
(Date:10/15/2014)... WASHINGTON, N.Y. , Oct. 15, 2014 /PRNewswire/ ... technology solutions for home and community-based care, today ... benefits of implementing Sandata,s Santrax® Electronic Visit Verification™ ... Care Services is a home health company founded ... Texas . The ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2Sandata Announces Case Study with Quality Care Services, Inc. 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
(Date:10/22/2014)... (PRWEB) October 22, 2014 Physicians ... its cardiovascular pharmacogenetics menu, which enables healthcare providers ... With PCLS’s evidence-based results, healthcare providers are ... optimize their therapy, while minimizing risks for adverse ... U.S., according to the FDA [1] more than ...
(Date:10/22/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... Oral Amphotericin B program.  The company recently announced ... work involving samples from HIV/AIDS patients exposed to ... clinical studies and regulatory filings to move forward ... approximately $700,000 of funding and technological advice from ...
(Date:10/22/2014)... SAN DIEGO and HONG KONG ... an innovative rare disease therapeutics enterprise, announced today that ... joined the company as vice president, research. Dr. McKew ... research, including key leadership positions at the National Institutes ... to its acquisition by Wyeth). Dr. McKew will lead aTyr,s ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
Cached News: