HOME >> BIOLOGY >> NEWS
UCSD biologists discover new class of genes responsible for embryonic development

Biologists at the University of California, San Diego have discovered in the roundworm C. elegans a new class of genes necessary for the normal development of the earliest stages of embryonic development in animals.

In the May issue of the journal Developmental Biology, the UCSD researchers report the discovery of a new class of genes that regulates the asymmetric division of the first cell in the developing embryo into an unequal sized pair of cells.

"The actual mechanisms by which this happens are not well understood," says Raffi V. Aroian, an assistant professor of biology at UCSD who headed the research. "By understanding more about the genes that regulate this process, we can provide more information about one of the key questions in developmental biology-how complex organisms such as humans develop from a single-celled embryo."

In normal embryos, the larger of these cells develops into the outer layers of an organism, such as its skin and nervous system, while the smaller of the two cells develops into the inner portions, such as its muscle, gut and reproductive organs. When one of the genes in this new class is defective, however, the absence of differences between the two cells prevents the differentiation necessary for development.

"If the asymmetrical division is screwed up, the embryo is never going to make it," says Akiko Tagawa, a graduate student and the lead author of the paper, which also includes Chad A. Rappleye, another graduate student working in Aroian's laboratory. "It quickly dies."

In addition, the cells containing these mutant genes are vulnerable to bursting and shriveling. This is due to the inability of the defective embryo's cell membranes to maintain the cell's osmotic pressure, which can produce an undesirable flood of fluids into or out of the cells.

The UCSD scientists have dubbed their new class pod genes-for polarity and osmotic defective genes-because mutations in them resu
'"/>

Contact: Kim McDonald
kimmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
30-Apr-2001


Page: 1 2

Related biology news :

1. Tracing genes, biologists show lizard migration is traced to Florida
2. UCLA molecular biologists uproot the tree of life
3. UCSD biologists develop super-endurance strain of mice
4. Springtime blooms seen earlier now than in the past, say Boston University biologists
5. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins
6. U of T microbiologists achieve results with pattern recognition software
7. Parting genomes: UA biologists discover seeds of speciation
8. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
9. Plant biologists Delmer, Quail, Bennetzen elected to National Academy of Sciences
10. New York microbiologists awarded research grants in antibiotic resistance and lyme disease
11. Purdue biologists expose the inner workings of viral machine

Post Your Comments:
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. ... interface solutions, today announced that members of the executive ... the Pacific Crest Global Technology Leadership Forum on Tuesday, ... conference will be held at the Sonnenalp Resort in ... The presentation may include forward-looking information. An audio webcast ...
(Date:7/31/2015)... , 31 de julho de 2015 ... www.icg-10.org ) será realizada pela BGI de 22-25 de ... . A conferência está celebrando seu 10 ... 2006, a ICG se tornou uma das reuniões mais ... dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale Konferenz ... BGI veranstaltet und findet vom 22. bis 25. ... , statt. Die Konferenz feiert ... Start 2006 ist die ICG weltweit zu einem ... Sie ist eines der dynamischsten, enthusiastischsten und angenehmsten ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
(Date:8/26/2015)... Aug. 26, 2015  The Diabetes Research Institute ... of Miami Miller School of Medicine, announced today ... to test for the first time a novel ... This FDA approved Phase I/II study builds upon ... is an important first step toward the development ...
(Date:8/26/2015)... 2015 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced that the Company has been informed that Magnum ... owned by Mr. Yuen Kam, chairman of the board ... shares (the "Shares") of  Excellent China Healthcare Investment Limited ...
(Date:8/26/2015)... ... August 26, 2015 , ... The 2015 Epigenomics & Metabolomics ... technology start-up company Asymmetrex to share the first report on progress with ... biomarker for counting adult tissue stem cells. , With a name like “H2A.Z asymmetry,” ...
(Date:8/25/2015)... DIEGO , Aug. 25, 2015 Human Longevity, ... Mark A. Winham has joined the company as Chief ... life sciences, medical operations and technical experience, will report directly ... In this new role as COO, Winham will ... pipeline operations as well as all facility operations. HLI currently ...
Breaking Biology Technology:Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2
Cached News: