HOME >> BIOLOGY >> NEWS
UCSD finds genetic time bomb in heart that leads to heart failure in some patients

urgery to close the hole.

"People have thought that congenital heart disease is cured by surgery, which is true for the short term," said the study's senior author, Kenneth Chien, M.D., Ph.D., professor of medicine and director of the Institute of Molecular Medicine at UCSD. "If a child is born with a hole in the heart, it can be patched. However, as these patients survive, it is now clear that there is an intrinsic, progressive problem with the heart that makes them get late stage heart failure and in certain cases, sudden death due to cardiac electrical problems." One of these patients was Dennis Appel of Vancouver, Washington who was born with an atrial septal defect in 1970. Although surgery at age 5 repaired the structural defect, he experienced irregular heartbeats in his 20s and had a pacemaker implanted when he was 22. Unexpectedly in 2001, at the age of 31, he suffered from a severe arrhythmia, or irregular heart rhythm.

According to his wife, Vicki, "he seemed fine. Then, he moaned and slumped forward on his stomach. When the paramedics came, they tried CPR because they heard a rhythm. But it turned out to be the pacemaker, which was working fine. Dennis was dead."

Appel was a member of a large Oregon family where multiple generations had inherited atrial septal defects, causing advanced AV node malfunction, and in some of the family, unexpected death. Heart tissue samples from affected family members who had a known defect in the Nkx2-5 gene were studied by researchers at Oregon Health & Science University (OHSU) in Portland and the Imperial College and Royal Brompton Hospital in England, in conjunction with the UCSD research team. A characteristic pattern of disease in the electrical system of the heart was found.

"This family almost uniformly had surgeries to correct the structural defects," said Michael Silberbach, M.D., an OHSU cardio
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
29-Apr-2004


Page: 1 2 3 4

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. DNA barcode finds four new bird species
3. Rice finds on-off switch for buckyball toxicity
4. Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
5. South Dakota Tech grad student finds rare whale
6. Purdue study finds antioxidant protects metal-eating plants
7. Medication reconciliation, pharmacist involvement vital to reducing medication errors, study finds
8. Scientist who discovered Sly syndrome finds new research path to explore for treating the disease
9. Study finds anti-HIV protein evolved millions of years before the emergence of AIDS
10. Drug prevents chemotherapy-induced hearing loss, study finds
11. Old is young, study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2020)... ... April 27, 2020 , ... ... was started by three teenagers with an idea to help millions of people ... the time of great need and suffering, an outlet has been created for ...
(Date:4/22/2020)... ... April 20, 2020 , ... RCH Solutions (RCH ), a ... sizes, announces the hiring of Michael Wlodarczyk as Director of Sales and Business Development. ... and grow the company’s already strong presence across the Northeast. , “We continue to ...
(Date:4/18/2020)... ... April 16, 2020 , ... SIRION Biotech GmbH , a ... announced it will present a company update on its work expediting gene therapy research ... place on April 22 and 23. Dieter Lingelbach, the Company’s Chief Operating Officer, will ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... May 21, 2020 , ... Threats to intellectual ... harm , Contrary to conventional wisdom that says the coronavirus pandemic will generally ... will emerge from the pandemic commercially weaker, dealing with delays in new product ...
(Date:5/15/2020)... ... May 14, 2020 , ... ... stem/stromal cell (hMSC) working cell banks and hMSC bioprocess systems, today announced ... multi-format collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is the only system ...
(Date:5/14/2020)... ... May 12, 2020 , ... DuPont Nutrition & Biosciences ... for all personal care ingredients in Russia and Belarus. Beginning May 1, Interdisp ... for personal care. , The GENENCARE®OSMS product line contains a range ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
Breaking Biology Technology:
Cached News: