UCSF/Gladstone Finding May Explain HIV'S Ability To Infect Cells Lacking The Key Target Of HIV: The CD4 Receptor

Researchers may have identified the molecular mechanism that enables HIV to cast its infectious net beyond those cells bearing the CD4 receptor, the loading dock that HIV normally first engages on a cell's surface.

The finding was presented earlier this week (February 1) at the Sixth Conference on Retroviruses and Opportunistic Infections in Chicago, by scientists from the Gladstone Institute of Virology and Immunology at UC San Francisco.

In their study, the investigators discovered that cells bearing the CD4 receptor sometimes interact with neighboring cells that lack the CD4 receptor but do bear a "co-receptor," or secondary loading site, such as CCR5 or CXCR4. Together, these proteins create a receptor complex that HIV recognizes as a single unit.

"This so-called `trans' mechanism expands the range of potential cellular targets for HIV-1," said the senior author of the study, Mark A. Goldsmith, MD, PhD, UCSF assistant professor of medicine at the Gladstone Institute.

It also suggests a possible new focus for drug therapies aimed at preventing the spread of HIV to non-CD4 receptor cells. "We still need to demonstrate this in rodent models," said Goldsmith, "but this is an intriguing start." HIV generally infects the immune system's T-cells, which reside in the blood, latching first onto the CD4 receptor and then onto the CCR5 co-receptor located on the same cell's surface. The multi-step binding process culminates with HIV's fusion with the cell.

However, the virus also migrates from the blood into tissues, infecting various types of cells in the brain, colon, testes, ovaries and heart. Some of these cells are immune system cells, some are not. Many are CD4-negative cells, such as cell's bearing CD8 receptors in lymphoid tissues; astrocytes and endothelial cells in the brain; epithelial cells in the colon; and myocytes in heart tissue.

While CD4-negative cells are not the principle target of HIV infection, studies indicate that th

Contact: Jennifer O'Brien
University of California - San Francisco

Page: 1 2 3 4

Related biology news :

1. AIDS Virus May Evolve Differently In Cerebrospinal Fluid Compared With Blood In Some Patients, UCSF/Gladstone Research Finds
2. Breakthrough In Understanding The Biology Of Fat-- UCSF/Gladstone Scientists Discover Gene For Key Enzyme
3. Findings suggest need for new view of p53 cancer proteins interaction with DNA
4. Finding the hole in the defenses of cavity-creating microbes
5. Findings redefine mechanism of action of RNA helicase enzymes
6. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
7. Finding may help eczema sufferers tolerate smallpox vaccine
8. Findings could aid efforts to harness nature for making drugs
9. Findings offer clue to how molecule can both stimulate, suppress cell growth
10. Findings offer further understanding about growth and development in young male gymnasts
11. Findings in frog oocytes may help study of chromosome physiology

Post Your Comments:

(Date:8/7/2018)... BOSTON and SOUTH JORDAN, Utah (PRWEB) , ... August 07, 2018 ... ... communications and collaboration solutions, announced today their new CT Cloud Voice and SIP solutions. ... cloud delivering a scalable and secure, quality voice solution that is far superior to ...
(Date:8/2/2018)... (PRWEB) , ... August 02, 2018 , ... ... management solutions to pharmaceutical and biotech companies, today announced that Mark Jara, principal ... most inspiring people in the life sciences industry. Individuals named to PharmaVOICE 100 ...
(Date:8/1/2018)... ... July 31, 2018 , ... ... Awards at Global Conference , Awards honor late founder of Wisdom National Brands® ... National Brands, presented prestigious stevia awards to a renowned German professor and a ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... ... Foot Center of New York’s (FCNY) acquisition of several Erchonia low-level lasers, including ... podiatric medical education and clinical experience. Their students receive comprehensive academic training ...
(Date:7/24/2018)... ... July 24, 2018 , ... R3 Stem Cell is now ... The treatments are offered by Double Board Certified providers, with outcomes significantly improving patient ... suppressing symptoms, but have done nothing to help repair and regenerate damaged lung tissues. ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech S.A, ... Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under the ... with approximately $17m allocated towards the first Phase 3 study starting as early ...
(Date:10/13/2017)... KING OF PRUSSIA, PA (PRWEB) , ... October 13, 2017 , ... ... Group Vice President and Turesol Business Unit Leader, will moderate a discussion on the ... this year’s ISPE Annual Meeting & Expo . The theme of this year’s ...
Breaking Biology Technology:
Cached News: