HOME >> BIOLOGY >> NEWS
UCSF-led study raises doubts about marrow cell treatment for brain, heart

A study led by UCSF investigators indicates that bone marrow-derived cells from mice that are transplanted into other mice fuse with cells in the animals' heart, brain and liver, and take on their characteristics. The finding is significant in part because it offers strong, new evidence that bone marrow-derived cells do not actually differentiate into specialized cells themselves, a goal of some cell-transplant therapy.

The findings, reported in the advance, on-line issue of Nature on Oct. 12, contrast with previous studies that have suggested adult stem cells derived from the bone marrow -- a spongy tissue inside bones that makes blood cells -- were capable of specializing not just into blood cells, but into cells of the brain, heart and other tissues. These studies have raised hopes that cells that are progenitors of blood could be used to replace damaged tissue in critical organs.

The new findings provide the first indication that cell fusion, rather than differentiation, occurs when bone marrow-derived cells migrate to the heart and the brain of mice. They also support previous studies showing fusion of blood cells in liver, and in cell-culture.

Given this evidence, the researchers say, clinical trials to study whether implanted bone marrow-derived cells could be used to replenish damaged cells in patients with diseases of the heart, brain and liver should be postponed until more research has been conducted.

"Our study raises serious questions about whether bone marrow-derived cells are capable of trans-differentiation," says the senior author of the study, Arturo Alvarez-Buylla, PhD, professor of neurosurgery at University of California, San Francisco (UCSF).

"The finding raises major questions about the plasticity of adult blood stem cells," says co-author Sean J. Morrison, PhD, a Howard Hughes Medical Institute assistant investigator and assistant professor of internal medicine and of cell and development biology at
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
14-Oct-2003


Page: 1 2 3

Related biology news :

1. UCSF-led team reports new test improves detection of prions in animals
2. UCSF-led study points to pivotal, early event in cancer development
3. UCSF-led study offers insight into cancer development, resistance to therapy: finding focuses on Ras oncogene
4. Student science contest participation influences study, career choices, alumni say
5. New study shows hope for treating inhalant abuse
6. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
7. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
8. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
9. Phase II trials of second-generation antisense cancer drug planned following successful early study
10. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
11. Indiana University, EPA to study airborne PCBs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... salient features of seizure risk signals, usually based on variations of amplitude, frequency ... the only acceptable diagnostic methodology due to the complexity and variability of the ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University of Vermont Health ... BioFactura’s $6M Series B Financing Round. , “With the commitment from the ... significant financial and business resources to bear as we advance our biopharmaceutical products ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... in a live webinar on Wednesday, June 19, 2019 at 1pm ... teams, medical review teams, data management teams and contract research organizations (CROs) can ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
(Date:5/15/2019)... ... 16, 2019 , ... Emulsifiers are the magic bullet when ... rely on these ingredients to create stable quality food that can withstand shelf-life ... triggers food formulators to seek out alternatives for starches, gums and chemical emulsifiers. ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three thousand ... Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), during ... results of some research carried out by the association, in partnership with scientists ...
Breaking Biology Technology:
Cached News: