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UCSF researchers identify regulator of critical brain messenger, hinting at therapy

The researchers' next step is to study the channel and transporter-like properties of VGLUT1 and its related isoform in greater detail, to see if they contributes to changes in synaptic strength that underlie learning, memory and many other aspects of cognition. To determine the protein's role in behavior, they will also knock out the genes in mice.

Researchers previously thought the VGLUT1 protein played a very different role. They thought it was a protein that functions on the plasma membrane to transport inorganic phosphate into a neuron.


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Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
10-Aug-2000


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