HOME >> BIOLOGY >> NEWS
UF Researchers Use Gene Therapy To Prevent Hypertension, Organ Damage

rt Association estimates as many as 50 million Americans 6 and older have high blood pressure, and 35 percent of them do not know it.

High blood pressure is particularly prevalent in blacks, heavy drinkers, women taking oral contraceptives, and those who are middle-aged, elderly or obese.

Though high blood pressure is easily detected and usually controllable with daily medication, doctors are unsure whether this treatment reverses other hypertension-induced changes in the body, such as heart and kidney damage.

In the UF study, researchers treated rats genetically predisposed to high blood pressure with antisense, a form of DNA in which the normal genetic code is reversed. The antisense is packaged within an inactivated, harmless virus called a retrovirus and injected into the bloodstream. The antisense interacts with the cell wall to reduce the potentially harmful effects of the angiotensin II hormone. High blood pressure and organ damage were prevented in all of the animals in which the treatment was successfully delivered.

"There are a number of pathophysiological changes associated with high blood pressure, and we chose to look at six," said Gelband, an assistant professor of physiology in the UF College of Medicine. "All six of these problems were prevented. We now plan to study whether gene therapy can reverse organ damage in adult animals with high blood pressure."

Gene therapy studies for high blood pressure have been under way at UF for a number of years. M. Ian Phillips, professor and College of Medicine physiology department chairman, previously has shown gene therapy can reduce high blood pressure in adult animals.

Jeffrey Martens, a graduate student in pharmacology and the current paper's lead author, said gene therapy may someday offer an alternative treatment for people genetically predisposed to high blood pressure.

"We have not identified the gene that causes high blood pr
'"/>

Contact: John Lester
JCLester@ufl.edu
352-392-0186
University of Florida
2-Mar-1998


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Use Gene Therapy Prevent Hypertension Organ Damage

(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ... America Biomedical Sensors Market - Growth, Trends & Forecasts ... Latin America Biomedical Sensors market is estimated at $0.65 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/25/2015)... June 25, 2015 According ... Type (Swipe & Area), Technology, Material (Optical Prism, ... Commercial Security & Others) & Geography - Global ... the said market is expected to reach $14,500.07 ... Browse 76 market Tables and ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
(Date:6/29/2015)... Manhattan, KS (PRWEB) , ... June 29, 2015 ... ... US PATENT 7736892 B2. Under the terms of the agreement, MediVet will acquire ... Matrix Stem Cells (UCMSCs). MB-007 is currently in pre-clinical development as a potential ...
(Date:6/29/2015)... ... June 29, 2015 , ... The global ... during the forecast period (2015 to 2020). The market is mainly driven by ... corporate funding for R&D. However, lack of adequate healthcare and research infrastructure in ...
(Date:6/29/2015)... June 29, 2015 BioNano Genomics, Inc., the ... research institutes, announced today that a collaboration led by ... in the creation of the first comprehensive analysis of ... molecule methods for sequencing and genome mapping. This study, ... comprehensive analysis of the contiguous diploid human genome assembly ...
(Date:6/29/2015)...  AACC, a global scientific and medical professional ... is pleased to announce that the impact factor ... increased to 7.9 in the 2014 Thomson Reuters ... Chemistry in the top 3% of all ... the research it publishes on laboratory medicine and ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 2BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 3AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3
Cached News: