UI Researchers Find Potential Gene Therapy For Cystic Fibrosis

IOWA CITY, Iowa -- A team of University of Iowa investigators may have found a way to permanently deliver therapeutic genes to the lungs of patients with cystic fibrosis (CF), the most common fatal hereditary disease in the United States.

The research using human cells in laboratory cultures indicates that the method could be used to permanently cure CF and other genetic lung diseases, said Paul McCray, M.D., associate professor of pediatrics in the UI College of Medicine and co-principal investigator.

The findings were published in the December issue of the Journal of Virology. The other co-principal investigators of the study were Beverly L. Davidson, Ph.D., UI associate professor of internal medicine and director of the Gene Transfer Vector Core, and Guoshun Wang, Ph.D., UI research investigator in pediatrics.

According to the Cystic Fibrosis Foundation, CF affects approximately 30,000 children and young adults in North America. The disease occurs in approximately one of every 3,300 live births and is usually diagnosed in early childhood. Reduced lung function, lung infection and liver and pancreatic disease are among the serious conditions that can reduce the life expectancy of a person with CF. The median age of survival for a person with the disease is 31 years.

CF is caused by the malfunction of an ion channel that regulates secretion of salt and water that protect the lungs. A specialized protein, known as the CF transmembrane conductance regulator (CFTR), makes the channel. The gene that codes for the CFTR protein is mutated in people with CF. McCray said the UI research project was designed to complement other CF treatments under laboratory investigation, including another UI study. Those methods involve inserting the CFTR gene into a vector--a nonviral carrier or an adenovirus--to facilitate transferring the gene into cells lining the airway.

In some cases, the mucous produced by the diseased lungs may trap the vector and prevent

Contact: Becky Soglin
University of Iowa

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:9/3/2020)... YORK (PRWEB) , ... September 03, 2020 , ... ... real world data, today announced that an extensive third-party assessment of the company’s ... and compliant when measured against federal security regulations. The comprehensive evaluation reviewed Litmus’ ...
(Date:8/23/2020)... ... August 21, 2020 , ... The August edition of ... now available on the company’s global website. Crystallography Times—an electronic newsletter published by ... news and crystallographic research. , The latest issue of Crystallography Times introduces ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, ... have entered into license agreements with Housey Pharma’s HMI subsidiary to gain access ... J&J have annual Research and Development spending in excess of US $10 billion. ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners ... has announced the placement of Julianne Averill , CPA, as Chief Financial ... financial operations and implementing key business strategies to accelerate Alveo’s growth as the ...
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , ... of its Scientific Advisory Board (SAB) to research the medical potential of terpenes and ... enhanced when combined with terpenes. The board is focused on expanding the recently launched ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society announced ... Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of follow-on ... consortium of academic research centers in the United States and Europe with expertise ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today revealed ... in FDA compliance consulting has been named on its annual Inc. 5000 list, ... a unique look at the most successful companies within the American economy’s most ...
Breaking Biology Technology:
Cached News: