HOME >> BIOLOGY >> NEWS
UI Study Reveals Important Information About Molecular Defect In Limb Girdle Muscular Dystrophy

IOWA CITY, Iowa -- For the first time ever, University of Iowa researchers have confirmed how a protein complex, when defective, causes limb girdle muscular dystrophy.

This information could help scientists to develop new ways to treat limb girdle forms of muscular dystrophy. Limb girdle varieties affect between one in 20,000 and one in 50,000 individuals.

"We have established a cell culture system that we can use to mimic the defect in limb girdle muscular dystrophy," said Kevin Campbell, Ph.D., UI professor of physiology and biophysics, and neurology, and a Howard Hughes Medical Institute Investigator.

The UI findings appeared in a recent issue of the Journal of Biological Chemistry.

Campbell, along with Kate Holt, Ph.D., a postdoctoral fellow in Campbell's lab, used the cell culture system to find out how the protein complex, called the sarcoglycan complex, forms. The sarcoglycan complex, composed of four distinct transmembrane glycoproteins, is part of the dystrophin-glycoprotein complex, a group of proteins located in muscle cell membranes. The dystrophin-glycoprotein complex is thought to stabilize the membrane against contraction-induced damage. Past studies have shown that mutations to the sarcoglycan complex cause various types of limb girdle muscular dystrophy.

Muscular dystrophy is a group of diseases characterized by hereditary progressive muscle weakness and degeneration. The unifying theme among limb girdle varieties of the disease is the initial involvement of the shoulder and pelvic girdle muscles, with relative sparing of most other muscle groups.

Despite rapid advances regarding the genetic defects that cause limb girdle muscular dystrophy, researchers know little about the molecular defects underlying the disease. Through their cell culture model, Campbell and Holt were able to show that complete assembly of the sarcoglycan complex is dependent on the simultaneous synthesis of all four sarcoglycans. Any mutant sarcogly
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
4-Mar-1999


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 15, 2018 , ... Firmex today released new research on merger ... 480 investment bankers and M&A advisors worldwide to compile the third annual M&A ... key findings in the report. , Highlights in the 2018-19 Report:, ...
(Date:11/15/2018)... YORK (PRWEB) , ... November 14, 2018 , ... ... Sinai have developed a tool that speeds up the analysis and publication of ... researchers communicate results of their studies. Until now, the primary method available to ...
(Date:11/15/2018)... , ... November 14, 2018 , ... ... testing lab, will present new scientific evidence on gene-disease relationships and how it ... Meeting to be held in Atlanta, November 14-17. , Ambry has been ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... Calif. (PRWEB) , ... November 13, 2018 , ... , ... Beijing Office in China. With the increasingly growing demand for AFM technology in China, ... and industrial communities by opening an office in Beijing equipped with Park AFM. , ...
(Date:11/11/2018)... ... November 09, 2018 , ... Triple W, an innovator of ... Innovation Awards Honoree for DFree ®, the first health tech wearable device ... time to go to the bathroom. The announcement was made during CES Unveiled New ...
(Date:11/9/2018)... Fla. (PRWEB) , ... November 08, 2018 , ... ... in the United States, adopted a machine-learning powered approach to increasing recovery rates ... centered around an Artificially Intelligent Collections (AIC) product developed by NLP Logix, a ...
(Date:11/7/2018)... ... November 07, 2018 , ... ... a campaign to increase awareness of the adult tissue stem cell counting problem ... of November, the company is intensifying this effort with new educational publications and ...
Breaking Biology Technology:
Cached News: