UI researchers begin to unravel the underlying mechanism of migraines

Anybody who has ever battled through migraines knows just how agonizing they can be; however, nobody has ever figured out why the painful headaches persist as long as they do.

Until now.

University of Iowa researchers Paul Durham, Ph.D., a postdoctoral fellow in physiology and biophysics, and Andrew Russo, Ph.D., an associate professor of physiology and biophysics, have identified a feedback loop mechanism that could at least partially explain the prolonged nature of migraines. The UI researchers discovered that inflammatory agents released during a migraine might lead certain neurons in the head to increase the secretion of neuropeptides known as calcitonin gene-related peptides (CGRP). The CGRP then stimulates the release of additional inflammatory agents. This feedback loop results in continued secretion of CGRP and persistent pain for the person suffering the migraine.

"We are very interested in understanding the steps involved in controlling how CGRP is made and released from neurons during inflammation," Durham said. "Results from our research will likely identify potential therapeutic targets for the development of anti-migraine drugs that are more selective and potent than those currently available."

The UI investigators made their discovery while studying the anti-migraine drug called sumatriptan. Sumatriptan is the most effective anti-migraine drug currently available, alleviating migraine pain in 50 to 75 percent of patients. Although clinicians know that it works, they had not understood how it worked. Durham and Russo wanted to answer the questions of why CGRP levels were elevated during migraines and then how sumatriptan worked its migraine-zapping magic. Once they identified the feedback loop, the UI researchers were able to show that sumatriptan blocks this loop.

"The long-term goal of this finding is to take some of this information to drug companies so they can identify ways to make sumatriptan more effective or to develop n

Contact: Jennifer Cronin
University of Iowa

Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:

(Date:4/4/2019)... , ... April 02, 2019 , ... ... and development solutions for drugs, biologics and consumer health products, today announced that ... takes place at the Gaylord National Harbor Hotel, Oxon Hill, Maryland, on April ...
(Date:4/4/2019)... ... April 03, 2019 , ... R3 Stem Cell is now ... Centers of Excellence. R3 wants patients to feel secure when they make a ... from Centers that use inferior regenerative biologics, protocols or amounts, R3 provides a ...
(Date:3/29/2019)... ... March 28, 2019 , ... In the wake of ... entirely dedicated to Chinese biobanks was launched in July 2018, in an agreement ... Biobank Branch, China Medicinal Biotech Association (BBCMBA). The one-year pilot programme offered two ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny ... for approximately two months. After a series of diagnostics, an MRI was performed ... owner, Alison, researched the injury and found that VetStem Regenerative Cell Therapy ...
(Date:4/8/2019)... (PRWEB) , ... April 09, 2019 , ... ... disease, the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen ... of antibody repertoires is part of CZ Biohub’s efforts to establish new approaches ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the field ... to veterinarians across the United States and Canada since 2004. The primary indications ... tissue injuries in the dog, cat, and horse. Recently, VetStem teamed up ...
(Date:3/23/2019)... ... March 22, 2019 , ... ... LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary approach for the ... polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and ...
Breaking Biology Technology:
Cached News: