HOME >> BIOLOGY >> NEWS
UI researchers discover new activity in cystic fibrosis protein

Even well-studied proteins can reveal surprises. University of Iowa scientists have discovered a new enzyme activity for the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is the protein that is defective in cystic fibrosis, a common life-threatening genetic disease that affects primarily the lungs and pancreas of young people. The discovery, which appeared in the Dec. 26, 2003 issue of Cell, helps solve a long-standing puzzle about how this important protein works.

CFTR forms a channel, or pore, in the membrane of airway cells. When the channel is open, the salt chloride flows through it from one side of the membrane to the other. It has been known for many years that CFTR channel opening requires a molecule called ATP and that CFTR has an enzymatic activity called ATPase that uses ATP. ATP is the energy currency of the cell and the ATPase reaction spends the energy of ATP to power enzyme activity. Because chloride flows passively through the CFTR channel, it has long seemed puzzling that the opening of CFTR would require the substantial energy of ATP. Moreover, energy from ATP is not required to fuel any other ion channel.

The UI study now reveals that CFTR can function as an adenylate kinase enzyme. Like an ATPase, the adenylate kinase reaction uses ATP. But in contrast to an ATPase, an adenylate kinase enzyme also uses a related molecule called AMP. Importantly, the adenylate kinase neither consumes nor produces energy, but it controls channel opening. The study also suggests that in normal cells it is this enzyme activity rather than the ATPase that opens the CFTR channel.

"We think that in the normal physiologic context where AMP is present, CFTR would function as an adenylate kinase," said Christoph Randak, M.D., UI postdoctoral scholar in the UI Department of Internal Medicine and lead author of the study. "Thus, the CFTR channel may function without consuming a large amount of energy."

The UI study ma
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
27-Jan-2004


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... , ... April 25, 2017 , ... ... leading supplier of Common Lisp (CL) development tools, and market leader for ... includes key performance enhancements now available within the most effective system for developing ...
(Date:4/25/2017)... ... ... Leaders of Quorum Review IRB and Kinetiq , the consulting ... Association of Clinical Research Professionals (ACRP) 2017 Meeting & Expo with topics ... excited to present subject matter expertise on topics that impact the global clinical research ...
(Date:4/21/2017)... ... April 21, 2017 , ... The University of ... round funding to three startups through the UConn Innovation Fund. The $1.5 million ... startups affiliated with UConn. , The UConn Innovation Fund provides investments of up ...
(Date:4/20/2017)... ... April 20, 2017 , ... As part of ... explore challenging patient cases when screening for direct oral anticoagulant. When patients taking ... need for bridging parental anticoagulation especially for those at high risk of thrombosis ...
Breaking Biology Technology:
Cached News: