HOME >> BIOLOGY >> NEWS
UI researchers investigate regulation of immune system memory

IOWA CITY, Iowa If a person's immune system successfully fights off an infection, not only does that person recover, but they also acquire immunity against re-infection by that same pathogen. The ability of the immune system to remember pathogens it has already defeated, and to respond rapidly and effectively to them during future exposures, is the basis of vaccination strategies.

University of Iowa researchers, led by John Harty, Ph.D., associate professor of microbiology, are making progress in understanding how these complicated aspects of the immune response are controlled. The UI team has found that two molecules, perforin and interferon gamma, already known to participate in the fight against infections, are also responsible for regulating the size and nature of both the initial immune response and the residual protective immunity. The research findings were published in the Nov. 17 issue of the journal Science. The lead author, Vladimir P. Badovinac, Ph.D., and co-author Amy R. Tvinnereim, Ph.D., are both postdoctoral fellows in Harty's lab.

"It was thought that the only role for these molecules was to enable T cells to directly or indirectly destroy infected cells," Harty said. "We have identified another role for the molecules, as regulators that control how many T cells are generated in response to infection and how many of these cells survive and contribute to immune memory."

Harty added that this work reinforces a long-standing notion about the immune system, that it is able to use the same molecule for different functions.

"The immune system has learned to use and modify existing systems to do the jobs required to fight off infections," Harty said.

When an active immune system is confronted by a new foreign invader such as bacteria or a virus, it initially generates large numbers of T cells specific for the infectious agent. These expanded cells undergo a process known as differentiation and become cells that can actively fight
'"/>

Contact: Lynn Rose
Lynn-Rose@uiowa.edu
319-335-9585
University of Iowa
15-Nov-2000


Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: