HOME >> BIOLOGY >> NEWS
UIC scientists provide first images of HIV in living cells

In stunning color images using time-lapse microscopy, researchers at the University of Illinois at Chicago have for the first time captured the very earliest stages of HIV infection in living cells.

The researchers filmed individual HIV particles as they traveled to the nucleus of a human cell and began taking over its genetic machinery -- the first step in the destruction of the body's immune system that leads to AIDS.

The movies not only offer tantalizing glimpses of HIV in action, but provide visual proof that HIV enlists the assistance of its host to wreak havoc on the body's defenses.

The virus can be seen traveling along a part of the host cell's own skeletal framework of microtubules as it makes its way from the outer membrane to the nucleus. The virus hitches a ride aboard a multi-unit protein called dynein, commonly referred to as a molecular motor.

"Dynein is like a tractor trailer, the microtubules are the highway, and the HIV particles are the cargo," said David McDonald, assistant professor of microbiology and immunology at UIC.

McDonald and Thomas Hope, associate professor of microbiology and immunology at UIC, are co-authors of the study, which appeared Nov. 11 in the Journal of Cell Biology. Science magazine named the paper an "editor's choice" in its Nov. 22 issue, and it will be featured in an upcoming issue of Nature Cell Biology.

An editorial accompanying the paper said, "With the powerful approaches developed by McDonald et al. and the incredible progress in imaging single fluorescent molecules in living cells, ... important and fascinating questions of HIV cell biology can now be addressed."

Until recently, little was known about how HIV enters a cell. The virus is made of an outer shell, or envelope, and a core, referred to as a particle, which is composed of proteins and genetic material. When the virus attacks an immune cell, it fuses with the cell's membrane and releases its particl
'"/>

Contact: Sharon Butler
sbutler@uic.edu
312-355-2522
University of Illinois at Chicago
11-Dec-2002


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) application for ... Approval of this IND allows Sentien to initiate a Phase 1/2 study with ...
(Date:8/12/2020)... ... 2020 , ... Mosio recently announced its newly updated text ... of all sizes. With a focus on tracking symptoms and monitoring outbreaks as ... Mosio helps public health departments automate communications and provide more personalized care and ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... II contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense ... to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... After research ... The completion of a great surgery is only the beginning of a successful study, ... research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/10/2020)... ... July 09, 2020 , ... PathSensors Inc., ... has expanded the company’s exclusive license to include clinical applications for CANARY™ ... market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast and highly ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a leading ... despite many obstacles created as a result of COVID-19. As a provider at ... medical practices and medical manufacturers by expanding access to device offerings, technology services, ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
Breaking Biology Technology:
Cached News: