HOME >> BIOLOGY >> NEWS
UMBI licenses HIV rat to Harlan

the disease to humans.

The HIV transgenic rat is an excellent model for tracking of the clinical, cellular, and immunologic course of HIV-1 in humans. According to Bryant, "It will be especially effective in testing potential therapeutic strategies against chronic AIDS-associated conditions or syndrome."

By five to nine months of age, the HIV-1 transgenic rats develop clinical signs similar to those of AIDS in humans, including weight loss, skeletal muscle atrophy or "wasting," neurological abnormalities, and respiratory problems. Many of the rats also suffered from mild-to-severe skin lesions, kidney disease, and cardiac disorders, all of which have been reported in chronically HIV-infected humans.

The HIV rats are also more efficient than mouse models for blood and tissue specimens. Organ studies are also easier with the larger animals.

In the context of worldwide HIV studies, Bryant adds, "It is hoped that this will allow the development of drugs for prevention of many of the chronic disorders that occur in AIDS patients. And in the long run this is an important building block, a small animal model through transgenic technology, which will also accelerate vaccine work."


'"/>

Contact: Steve Berberich
berberic@umbi.umd.edu
301-990-4804
University of Maryland Biotechnology Institute
9-Oct-2002


Page: 1 2

Related biology news :

1. University of Arizona licenses patent for natural fungicide
2. Wake Forest commercializes new soy technologies through licenses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: