HOME >> BIOLOGY >> NEWS
UMHS researchers find clues to growing new jawbones in cancer patients after radiation therapy

ANN ARBOR, Mich. In limited attempts with individual patients, varying surgeons have found mixed success in a method of growing new human jawbones after radiation therapy to treat head and neck cancer. While some patients have seemed to respond well to the technique, called distraction osteogenesis, others have not.

Researchers at the University of Michigan Health System are looking at how and why distraction osteogenesis works by studying rats and have found clues to the uneven clinical results. They will present their findings Wednesday at the American College of Surgeons Clinical Congress in Chicago.

Distraction osteogenesis is a method of regrowing bone in which the fractured bone is pulled apart millimeters at a time. As the fracture begins to heal, surgeons tug the bone further apart, tricking the body into thinking it must still work to heal the fracture. The body then begins to grow new bone to fill in the gap.

In two studies, UMHS researchers looked at distraction osteogenesis for reconstruction of the jawbone after radiation therapy. In one, the rats were given a low dose radiation; in the second study, the rats got a high dose of radiation. In both studies, new bone was formed. But looking at the new bone under a microscope revealed that it was of poor quality. There were obvious holes within the tissue and the bone was thin and brittle, showing signs of osteopenia (a precursor to osteoporosis). The high-dose radiation resulted in even lower quality bone.

"Clinical researchers are significantly limited in their ability to analyze their success and failure at the level of the bone. It would be difficult and invasive to take specimens from an actual patient's bone after reconstruction and study the quality and strength. With our rat model, we can cut out the new bone and examine it. We can show that although you can distract, there are some problems with the bone after radiation, and we can determine what those problems ar
'"/>


22-Oct-2003


Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ... 2019 , ... Cambridge Innovation Institute (CII) is pleased to ... which includes four annual Internet of Business (IoB) events in the U.S., consisting ... Kuhl, President, Cambridge Innovation Institute, says, "We are delighted to be able to ...
(Date:2/11/2019)... (PRWEB) , ... February 11, 2019 , ... ... DNA analysis products and services, announced a new forensic genealogy service offering to ... combines advanced DNA testing and genealogy to develop ancestral relationships between samples ...
(Date:2/2/2019)... ... January 31, 2019 , ... ... genomics, has awarded microbiome research support in study design, planning, sample collection, and ... Professor of Obstetrics and Gynecology, and Dr. Sara Vaughn, MD, Reproductive Endocrinology and ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... ... January 22, 2019 , ... Controlled Contamination Services is ... in the US. Each of these valuable new team members will support its growing ... model moving forward as CCS scales its business. This addition will enable CCS to ...
(Date:1/24/2019)... ... January 22, 2019 , ... ... has its own set of assumptions, and RFP creation and management generally requires ... is like comparing apples to oranges. These challenges can ultimately lead to study ...
(Date:1/21/2019)... ... 2019 , ... Microbial Discovery Group (MDG), a leading Bacillus ... cleaning market. MDG’s SporActiv liquid and powder product line contains safe ingredients that ... floor and tile cleaners, carpets, drains, portable restroom cleaning and more. , ...
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers are directing healthcare ... of physicians. That's changing as many services now exist for patients to order ... market totaled $208 million in 2018, according to Kalorama Information’s new report, ...
Breaking Biology Technology:
Cached News: