HOME >> BIOLOGY >> NEWS
UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch

CHAPEL HILL, N.C. --In a scientific first, researchers at the University of North Carolina at Chapel Hill have reduced the severity of arthritis by turning off a molecular switch, a gene called NF-kappa B.

A report published Nov. 10 in the Proceedings of the National Academy of Sciences says the findings, based on experiments in laboratory rats, establish an important molecular mechanism in human rheumatoid arthritis. The findings demonstrate the feasibility of new ways to treat the disease, including gene therapy.

"These findings underscore NF-kappa B as a very attractive target for arthritis treatments, including a new generation of drugs targeted specifically to the molecule," says the team's leader, Dr. Sergei S. Makarov, research assistant professor of medicine at the UNC-CH School of Medicine and the Thurston Arthritis Research Center.

"In rheumatoid arthritis, the delicate synovial joint lining dramatically expands and transforms into an aggressive, tumor-like structure that invades and erodes the joint," Makarov says. "We started studying the role for NF-kappa B in arthritis because it controls the expression of numerous inflammatory genes, and we knew that it's activated within the arthritic synovium. Around that time, our collaborator, Dr. Al Baldwin, published his pioneer study demonstrating that activated NF-kappa B is needed to protect cancer cells in vitro from apoptosis, or programmed cell death."

From their subsequent in vitro studies, Makarov and his colleagues learned that similar mechanisms might operate in rheumatoid arthritis. "We found that inflammatory stimuli caused activation of NF-kappa B inside the cells from arthritic joints, rendering them resistant to apoptosis. It seemed that the more inflammation you had, the more protected those cells were against apoptosis," he says.

"We then predicted that if you block NF-kappa B in the arthritic joint, inflammation would go down, the cells would no longer be protected ag
'"/>

Contact: Lynn Wooten
lwooten.est1@mail.unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
2-Nov-1998


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... MOUNTAIN VIEW, Calif. (PRWEB) , ... March 13, 2019 , ... ... for up to 45 percent of the world’s population. One billion ... person's breathing is interrupted during sleep - more than 80 percent of whom go ...
(Date:3/12/2019)... (PRWEB) , ... March 12, 2019 , ... ... strong multi-factor authentication and combined technology all-in-one smart cards, announced today the launch ... strong authentication: the Fingerprint Biometric and Dynamic CVV Payment cards. These advanced technologies ...
(Date:3/9/2019)... (PRWEB) , ... March 07, 2019 , ... ... and infectious disease diagnostics and automation – is pleased to announce the launch ... control resource giving customers access to lot-specific information, including pattern images for AESQC ...
Breaking Biology News(10 mins):
(Date:3/9/2019)... ... March 08, 2019 , ... ... planning, announced the release of their Best Online Master's in Biotechnology Programs ... on curriculum quality, program flexibility, affordability, and graduate outcomes. , In addition ...
(Date:3/4/2019)... ... March 04, 2019 , ... Stay on top of current hot topics through free webinars ... webinars is free, so be sure to register today to save your place! Participate in ... our upcoming webinars: , CLINICAL TRIALS, , March 20 – Implementing ...
(Date:2/26/2019)... (PRWEB) , ... February 26, 2019 , ... ... 2012 when Visikol Co-Founder Dr. Thomas Villani developed the Visikol® tissue clearing technology ... and has since transitioned from a products focused company to primarily a services ...
(Date:2/22/2019)... ... 2019 , ... Ocean Tomo Transactions, LLC will auction a ... patents in lot 92 relate to innovation for verifying human users ... users and computers through exploiting the fundamental differences between computer-based vision and human ...
Breaking Biology Technology:
Cached News: