HOME >> BIOLOGY >> NEWS
UNC awarded $5 million NIH grant to explore disease that inflames blood vessels

CHAPEL HILL - A groundbreaking $5 million federal grant to the University of North Carolina at Chapel Hill School of Medicine could help researchers find the cause of an often debilitating blood vessel inflammation of the kidneys, lungs, skin, heart, and other organs.

The grant from the National Institute of Diabetes and Digestive and Kidney Diseases will support a series of investigations into ANCA vasculitis, a disease encompassing several overlapping conditions of small blood vessel inflammation (including Wegener's granulomatosis).

"This grant will let us explore the cause of the disease so we can figure out a better treatment," said Ronald J. Falk, MD, professor of medicine at the university, nephrology division chief, and a pioneering vasculitis researcher.

Ten years ago, Falk and his Carolina colleague J. Charles Jennette, MD, professor of medicine and chair of pathology and laboratory medicine, were the first to suggest that specific antibodies found in patients with small vessel vasculitis were the disease triggers.

These are the two types of ANCA autoantibodies discovered about ten years ago, one by researchers in the Netherlands, the other by Falk and Jennette. ANCA means anti-neutrophil cytoplasmic antibodies.

In ANCA vasculitis, the body begins producing antibodies against specific components within neutrophils, which are leukocytes or white blood cells packed with potent infection-fighting granules. ANCA antibodies explode neutrophils, and when released, their granules help trigger inflammation.

"The disease is a 'kissing cousin' of another cause of vascular inflammation known as systemic lupus erythematosis, Falk said. "Each year, based on figures in the UK, ANKA vasculitis strikes an estimated six to ten people per million population. The UK figures apply to the United States, although ANCA vasculitis may, in fact, be more common here."

Why ANCA get produced, how they
'"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
3-Oct-2000


Page: 1 2

Related biology news :

1. Ecology of infectious diseases grants awarded
2. Joslin President awarded medal from international diabetes organization
3. UNC researchers awarded $8.65 million from National Institute on Aging
4. ESA awarded new SEEDS grant
5. $5.5 million awarded to tree-ring research and climate studies
6. Dartmouth Medical School awarded $9 million grant for genomics research
7. BioTime awarded NIH grant to aid Hetacool development
8. New York microbiologists awarded research grants in antibiotic resistance and lyme disease
9. Researchers awarded $2 million to create high-tech tools for fighting wildfires
10. USC awarded $3.5 million to study DNA enzyme
11. Young scientists awarded for achievements in cancer research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
(Date:7/10/2020)... , ... July 08, 2020 , ... ... Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • ... comparability study, but what is the most effective way to complete one? Will ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners , ... announced the placement of Julianne Averill , CPA, as Chief Financial Officer ... operations and implementing key business strategies to accelerate Alveo’s growth as the company ...
(Date:8/15/2020)... Ariz. (PRWEB) , ... August 13, 2020 , ... ... on its annual Inc. 5000 list, the most prestigious ranking of the nation’s ... companies within the American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics ... , Known as MediVet Biologics since its formation in 2016, the company ... Ardent Animal Health will build on its base of innovative therapies for osteoarthritis and ...
Breaking Biology Technology:
Cached News: