UNC scientist finds chief AIDS cancer needs trauma and virus to get started

CHAPEL HILL -- Kaposis sarcoma, the most common cancer that develops as people with the HIV virus progress to full-blown AIDS, appears to require some kind of trauma such as a cut or comparable injury to get started, a University of North Carolina at Chapel Hill scientist has discovered.

We found that there are at least three key elements central to development of this important cancer, said Dr. Jennifer Webster-Cyriaque, assistant professor of dental ecology and microbiology at the UNC schools of dentistry and medicine.

One is suppression of the immune system, which HIV causes. The second is the presence of human herpesvirus 8, or HHV8, which Dr. Yuan Chang and her husband Dr. Peter Moore of Columbia University discovered in 1994. And the third, which is new, is trauma after which the healing process begins to take place.

Webster-Cyriaques report on the findings appears in the current (April 18) issue of the New England Journal of Medicine.

What apparently happened to kick-start Kaposis sarcoma in one of her patients was that the natural healing process called in certain cells to help restore the damaged tissue, she said. But since those cells already were infected with the cancer-causing HHV8, that caused a malignancy to develop.

The report describes a 38-year-old HIV-positive patient participating in a UNC study of HIV-associated salivary gland disease. Researchers collected blood and throat secretions from the man and, in minor surgery, removed a tiny amount of salivary gland tissue for analysis.

The biopsy went fine, and we found the HHV8 virus in his throat washings, but not in his blood or salivary glands, Webster-Cyriaque said.

Several days after the biopsy, he came back with a significant lesion growing inside his lip at the biopsy site, she said. We sent him home with antibiotics to make sure the growth didnt become super-infected, but it continued to grow and soon extended outward to his chin

Contact: David Williamson
University of North Carolina at Chapel Hill

Page: 1 2

Related biology news :

1. EMBO Gold Medal 2004 goes to Spanish scientist
2. DNA lends scientists a hand, revealing new chemical reactions
3. UCSF scientist Joe Derisi named MaCarthur Fellow
4. Conference at UH opens doors for new scientists, engineers
5. Wisconsin scientists develop quick botox test
6. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
7. Alaska scientists find Arctic tundra yields surprising carbon loss
8. DuPont scientist named one of the worlds top young innovators by MITs Technology Review Magazine
9. UAF scientists discover new marine habitat in Alaska
10. Information system to help scientists analyze mechanisms of social behavior
11. White House to honor UNC School of Medicine scientist for early career achievement

Post Your Comments:

(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... Calif. (PRWEB) , ... August ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed their ... CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary focus ...
(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased to announce ... online store are now live. Sierra has redesigned entry to the site with both ... more user-friendly and easier to navigate with streamlined menus and simple access to resources ...
Breaking Biology News(10 mins):
(Date:8/15/2019)... ... 2019 , ... PathSensors announced today that Roger Lawrence has ... Institute of Food Technologists (IFT) Board of Directors, Illinois Institute of Technology (IIT) ... Safety and Applied Nutrition (JIFSAN) Advisory Council and the University of Maryland College ...
(Date:8/7/2019)... ... August 07, 2019 , ... Locus Agricultural Solutions (Locus ... of soil amendments (soil “probiotics”), including Rhizolizer ® , which is pulling up ... impact any approach has offered to date. Results from the treatment of almonds, cherries, ...
(Date:8/6/2019)... ... August 06, 2019 , ... The ... the launch of a community project that will engage middle and early high ... project, entitled “A Youth-Led Citizen Science Network for Community Environmental Assessment.” Collaborative partners ...
(Date:7/23/2019)... ... July 22, 2019 , ... While ... services in the fields of 3D tissue imaging , digital pathology ... initially started back in 2013 as a products company. These products are focused ...
Breaking Biology Technology:
Cached News: