HOME >> BIOLOGY >> NEWS
UNC scientist finds chief AIDS cancer needs trauma and virus to get started

. A second biopsy revealed it to be Kaposis sarcoma.

The rapidly growing tumor required radiation treatments and finally disappeared six weeks after radiation therapy began. It has been gone now for more than two years.

Through studies of the biopsied tumor tissue we found virus in macrophages, which are Pac Man-like scavenger cells that fight infection and also promote wound healing, the dentist and microbiologist said. We also found viral genes expressed for the first time in epithelial cells and in both white cells called lymphocytes and endothelial cells in tissues and blood vessels around the wound.

Endothelial cells eventually evolve into spindle cells, which are commonly seen in Kaposis sarcoma, but not in healthy people.

This work appears to explain why -- when some people have surgery, including transplant patients -- they develop Kaposis sarcoma at their suture sites, Webster-Cyriaque said. It also suggests that anti-viral agents targeted specifically at HHV8 could be useful in preventing Kaposis sarcoma in people whose immune systems have been suppressed, such as transplant patients.

The research is the first demonstration that HHV8 virus can be detected in saliva prior to disease development, she said. Previous studies examined blood to detect the virus before Kaposis sarcoma lesions developed but not saliva.

Looking only at blood, we would have missed it, said Webster-Cyriaque, a member of UNCs Lineberger Comprehensive Cancer Center and Center for Inflammatory Diseases.

Kaposis sarcoma is a particular problem for gay men in the United States, older, heterosexual men in countries surrounding the Mediterranean Sea, including Spain and Italy, and people in African nations.


'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
19-Apr-2002


Page: 1 2

Related biology news :

1. EMBO Gold Medal 2004 goes to Spanish scientist
2. DNA lends scientists a hand, revealing new chemical reactions
3. UCSF scientist Joe Derisi named MaCarthur Fellow
4. Conference at UH opens doors for new scientists, engineers
5. Wisconsin scientists develop quick botox test
6. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
7. Alaska scientists find Arctic tundra yields surprising carbon loss
8. DuPont scientist named one of the worlds top young innovators by MITs Technology Review Magazine
9. UAF scientists discover new marine habitat in Alaska
10. Information system to help scientists analyze mechanisms of social behavior
11. White House to honor UNC School of Medicine scientist for early career achievement

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... Calif. (PRWEB) , ... August 05, 2019 , ... Keck ... the KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly ... Board of Trustees Chairman Jim Widergren. “He is a great choice to build on ...
(Date:8/4/2019)... , ... August 02, 2019 , ... ... the life science industry in advancing the development of medical therapies, announced today ... by PharmaVOICE magazine as one of the “100 Most Inspiring People in the ...
(Date:8/1/2019)... , ... July 31, 2019 , ... ... today announced the launch of the next generation of its FLIPR® Penta High-Throughput ... of the industry-leading FLIPR® platform for monitoring of G-protein-coupled receptors (GPCRs) and ion ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the ... the appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings ... lend his healthcare expertise and extensive background in laboratory and scientific products manufacturing, ...
(Date:8/6/2019)... ... August 06, 2019 , ... Shoreline ... down to the strain level, has announced partnerships with six international distributors. ... companies and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, Myanmar, New Zealand, ...
(Date:7/26/2019)... , ... July 25, 2019 , ... ... leaders through off-the-record collaboration and dialogue, today announces its Boston BD ... Hotel. As part of Biotech Week Boston , the event provides an ...
(Date:7/17/2019)... ... July 16, 2019 , ... Catalent ... of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis gene therapy treatment for spinal muscular ... dedicated manufacturing space at the new, state-of-the-art commercial manufacturing center near Baltimore-Washington ...
Breaking Biology Technology:
Cached News: