HOME >> BIOLOGY >> NEWS
UNC to test virus treatment for recurrent head and neck cancer

Chapel Hill - The University of North Carolina at Chapel Hill School of Medicine is one of nine medical centers nationally trying to determine if injections of a genetically modified common cold virus may be an effective treatment for recurrent head and neck cancer.

Under investigation is a form of adenovirus that's modified to selectively infect and destroy tumor cells only.

Unmodified, adenoviruses can infect and multiply in both cancer and normal cells, thereby killing all cells. One of the genes that enable the virus to replicate is E1B. This gene's protein inactivates the tumor suppressor gene, p53, which normally protects the cell from adenovirus infection. "Unless p53 is inactivated, adenoviruses cannot replicate," explained Wendell G. Yarbrough, MD, assistant professor of otolaryngology/head and neck surgery at UNC-CH. "About 50% of malignant head and neck tumors are made of cells with an inactivated p53 gene. Cancer cells are the only cells in the body in which p53 has been inactivated allowing for specific killing of cancer cells by the modified virus." Adenovirus with a mutated or deleted E1B gene will not produce the protein needed to inactivate p53. This means the virus replicates only in tumor cells, not in normal ones.

"And when this virus gets in a cancer cell with inactivated p53, it replicates, makes new adenoviruses, and then as part of its normal life cycle, it lyses or kills that cell and releases viruses that can then infect adjacent cancer cells," Yarbrough said.

Yarbrough, the principal investigator for UNC in this clinical trial, said therapy using E1B-mutated adenovirus ties in with his basic research on the gene ARF, an activator of p53. "In fact, we're now combining ARF with this virus to look at the effect of this combination on tumor cells."

The researcher notes that previous studies using adenoviruses as cancer therapy have relied on viruses unable to replicate. But the modified adenovirus developed by Ony
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
13-Mar-2001


Page: 1 2

Related biology news :

1. Pacific Northwest team unveils largest virus proteome to date
2. No role for simian virus 40 in human pleural mesotheliomas
3. Cannabis may help combat cancer-causing herpes viruses
4. Scientists find nanowires capable of detecting individual viruses
5. $7.5 Million grant to Yale researchers for role of viruses in cancer
6. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
7. Common cold virus can cause polio in mice when injected into muscles
8. Defensive action by influenza viruses demonstrated by Hebrew university researcher
9. Study of flu patients reveals virus outsmarting key drug
10. Images reveal how rotavirus - leading cause of diarrhea - enters cells
11. Bright idea could doom cancer and viruses, say Purdue scientists

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UNC test virus treatment for recurrent head and neck cancer

(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
Cached News: