HOME >> BIOLOGY >> NEWS
UPCI Researchers Find Drug Improves Cancer-Fighting Ability Of Vitamin D

PITTSBURGH, Jan. 20 -- A steroid drug enhances the ability of a vitamin D analogue to kill cancer while reducing a potentially serious side effect of vitamin D therapy, according to investigators at the University of Pittsburgh Cancer Institute (UPCI). Their findings on dexamethasone and the vitamin D derivative, 1,25-dihydroxyvitamin-D3, (1,25-D3), in an animal model are reported in the Jan. 21 issue of the Journal of the National Cancer Institute.

"We were very excited to find that not only did dexamethasone reduce hypercalcemia associated with 1,25-D3 , it actually improved the ability of 1,25-D3 to kill cancer cells in an animal model," noted Candace Johnson, Ph.D., study investigator, interim director for basic research at UPCI and co-director of UPCI's Molecular Oncology/Drug Discovery Program.

"We have previously shown that 1,25-D3 effectively halts the growth of cancer in animals, and we have conducted preliminary trials of this agent in men with advanced prostate and other cancers. However, the use of 1,25-D3 has been limited because this drug causes a potentially life-threatening increase of calcium in the blood," said Donald Trump, M.D., an investigator on the study, deputy director for clinical investigations at UPCI and director of the UPMC Health System's division of medical oncology.

UPCI investigators were among the first to describe the anti-tumor activity of vitamin-D compounds, or analogues, and showed that they arrest cancer growth in culture and in animals. While other researchers had previously shown the effect of vitamin D analogues in leukemia cells, Dr. Johnson and Dr.Trump were among the first to demonstrate the efficacy of these agents against solid tumors such as prostate cancer and head and neck cancers. Currently, the UPCI team is conducting a clinical protocol combining a steroid with 1,25-D3 for advanced cancer.

Dexamethasone appears to enhance 1,25
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
(412) 624-2607
University of Pittsburgh Medical Center
20-Jan-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... Rochelle, Virginia (PRWEB) , ... August 20, 2020 ... ... announced today that Hassan Movahhed , a Clinical Operations executive with expertise ... CRO management, has joined the firm as an Expert Consultant. Throughout his career, ...
(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid ... Wharton’s jelly allografts to be assigned a Q code and be approved for application ... jelly allograft product to be recognized as a 361 HCT/P by CMS regulated under ...
(Date:7/18/2020)... SAN ANTONIO (PRWEB) , ... July 16, 2020 ... ... PLOS ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise ... (NICU) environment. The study reported that the Neoasis™ device attenuated the alarm sounds ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES ... , Bode-CARES provides a turnkey solution that includes a comprehensive collection ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
Breaking Biology Technology:
Cached News: