UPCI presents study on discovery of protein that suppresses dendritic cells

PITTSBURGH, April 5 Researchers at the University of Pittsburgh Cancer Institute (UPCI) will present their findings at the 93rd annual meeting of the American Association for Cancer Research being held April 6-10 at the Moscone Convention Center in San Francisco.

Protein found to play an important role as a molecular switch in the survival and demise of dendritic cells
Embargoed until Sunday, April 7

University of Pittsburgh researchers have discovered that a protein, cdc42, plays an important role in the survival of dendritic cells in cancer. Their study showed that cdc42 was upregulated in dendritic cells treated with tumors, suppressing their activity, and that dendritic cells grew when the expression of cdc42 was decreased. The study further demonstrated that dendritic cells treated with tumors not only expressed higher levels of cdc42, but also expressed 15-fold less of a cdc42 inhibitor (Rho-GD-1) and 5.7-fold more of a cdc42 activator (ezrin).

The discovery of an increasing number of genes regulating dendritic cell activity and a better understanding of the molecular interactions between immune cells has provided the molecular basis for specific approaches of active immunotherapy in cancer patients, said Michael Shurin, M.D., Ph.D., associate professor of pathology at the University of Pittsburgh and associate director of clinical immunopathology. This new direction, which one could term therapeutic molecular immunopathology, will allow us to identify new molecular targets in dendritic cells and to possibly design new therapeutic approaches for cancer by genetically engineering the cells to protect them from tumor-induced apoptosis. This can translate into new possibilities for the creation of highly efficient vaccines for cancer therapy.


Contact: Clare Collins
University of Pittsburgh Medical Center

Page: 1

Related biology news :

1. DFG presents the 2004 MAK and BAT value lists
2. VIB presents its annual results at BIO2004 in San Francisco
3. Steroid-coated DNA represents new approach to gene delivery
4. ASH presents advocacy awards to Sen. Dianne Feinstein and Claude Lenfant, M.D.
5. DFG presents the new MAK and BAT Value List 2003
6. Center for Health Law and Policy presents program on bioterrorism measures and civil liberties
7. Agriculture presents common ground for rural, urban people
8. UPCI presents study on estrogenic activity of medicinal botanicals
9. UPCI presents study on dendritic cells in prostate cancer
10. USF presents new research on hyperlipidemic children
11. Biomedicines presents promising results from phase II trials of omega interferon for the treatment of hepatitis C

Post Your Comments:

(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
Breaking Biology Technology:
Cached News: