US researchers find first conclusive evidence that lead is linked to male infertility

US fertility experts today (Thursday 6 February) published the first conclusive evidence that lead is linked to male infertility.

A report in Europe's leading reproductive medicine journal Human Reproduction[1] concludes that exposure to lead damages sperm function and may be a contributory cause of unexplained male infertility.[2]

The findings have led principal investigator Dr Susan Benoff to urge doctors to measure lead in seminal plasma when evaluating men from couples with unexplained fertility. She also believes there is a case for health and safety authorities to continue re-evaluating environmental exposure limits.[3]

Dr Benoff, director of the Fertility Research Laboratories at the North Shore-Long Island Jewish Research Institute in Manhasset, New York, and colleagues from several other US institutions, undertook a prospective, double-blind study of metal ion levels and sperm function in semen from the partners of 140 consecutive women undergoing their first IVF cycle.

They found that lead levels in seminal plasma varied over a wide range and there was a significant association between high lead levels and a low fertilisation rates, with changes in lead levels accounting for a fifth of the variance in fertilisation rates.

"From our tests on lead in the seminal plasma of the participants and control experiments on nine fertile donors, we have evidence that higher lead levels interfere both with the ability of the sperm to bind to the egg and with its ability to fertilise the egg," said Dr Benoff.

In order to fertilise an egg, a sperm has first to bind to it. A sugar called mannose on the outer coating of the egg is crucial to binding. Mannose receptors located on the head of human sperm recognise the mannose on the coating of the egg and regulate the binding process.

Then the sperm has to penetrate the egg. Successful binding induces an event called mannose-induced acrosome reaction the release of

Contact: Margaret Willson
European Society for Human Reproduction and Embryology

Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
(Date:9/24/2015)... 24, 2015  EyeLock LLC, a market leader of ... winning and latest technology in Booth #602 at next ... . EyeLock,s iris authentication technology provides an ... accuracy, making it the most proven way to authenticate ... technology to deliver a fast and friendly user experience ...
(Date:9/10/2015)... Sept. 10, 2015 Report Details ... Reveals Selling Opportunities and Revenue Prospects to Help ... of biologics, especially new drug classes? Get the ... ahead with exclusive market data and industry knowledge, ... developments, results, opportunities and sales predictions. Visiongain,s ...
(Date:9/10/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that the ... Modern, will feature the Wocket® smart wallet for the ... Touch Of Modern is an online ... to its 7.2 million members. Customers are affluent, urban ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... , October 8, 2015 ...   --> Goldman Small Cap Research, ... small cap and microcap sectors, announced today that ... on PharmaCyte Biotech, Inc. (OTCQB - PMCB), a ... developing and preparing treatments for cancer and diabetes. ...
(Date:10/8/2015)...  The ALS Association, in partnership with Prize4Life, is ... revolutionize communication technology solutions for people living with ALS. ... (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that ... spinal cord. Eventually, people with ALS lose the ability ... to total paralysis and death within two to five ...
(Date:10/8/2015)... , ... October 08, 2015 , ... Talon Innovations, a ... Aerospace and other technology-driven industries, announces that it is one of three finalists for ... Midsize Company.” On Thursday, September 25 Talon Innovations was recognized as a nominee ...
(Date:10/7/2015)... MARLBOROUGH, Mass. , Oct. 7, 2015 ... week announced the start of the Boston Scientific ... to encourage advancements in the use of remote patient ... clinicians, engineers, designers and entrepreneurs can submit their ideas ... networking site ( www.Medstro.com ). Cambridge, ...
Breaking Biology Technology:
Cached News: