HOME >> BIOLOGY >> NEWS
UT Southwestern named one of 10 NIH centers for 'Human Proteome Project'

DALLAS Oct. 9, 2002 UT Southwestern Medical Center at Dallas is one of 10 U.S. institutions to be awarded a multimillion-dollar National Institutes of Health grant to develop faster methods to study proteins that are critical to drug development.

The grant is part of the NIH's National Heart, Lung and Blood Institute's Proteomics Initiative, a $157 million, seven-year program. The Southwestern Center for Proteomics Research will use the $16 million grant to develop new protein-focused technologies.

The "Human Proteome Project" has been likened to the Human Genome Project, only more difficult. The genome all the DNA of an organism is the formula for making proteins. Proteins are the cellular workhorses that carry out genetic orders for major functions like triggering growth and battling diseases. Scientists around the world are now working to describe all the proteins and how they interact with each other.

Dr. Thomas Kodadek, professor of internal medicine and molecular biology and the grant's principal investigator, said the funds from the NHLBI would be used to create tools to study G protein-coupled receptors (GPCRs) and transcription factors. Studies of these proteins have been limited because GPCRs are difficult to isolate and transcription factors are rare in comparison to other proteins.

"For different reasons, those classes of proteins have been under the radar of traditional proteomics, but they are very important for the regulation of physiological responses," Kodadek said.

These receptors are found in cells' outer membranes. They are known to bind signaling molecules and initiate chain reactions that launch genetic programs in the nucleus. Kodadek said a major goal for the grant is to develop GPCRs arrays flat panels with many different GPCRs arranged in a matrix on the surface. Scientists could introduce a drug or other substance on an array to study multiple GPCRs' responses simultaneously. Because membrane
'"/>

Contact: Wayne Carter
Wayne.Carter@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
9-Oct-2002


Page: 1 2 3

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... August 28, 2018 , ... ... unlocking the full power of positron emission tomography (PET), today launched its ... Dx is helping clinicians and researchers study and cure debilitating diseases, earlier, ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... clinical diagnostic laboratories. However, this technology introduces many well-described challenges around data ... leads the South London NHS Genomic Medicine Centre. The Viapath Genetics Laboratories ...
(Date:8/23/2018)... Calif. (PRWEB) , ... August 21, 2018 , ... ... engineer the genomes of diverse cell types and species for the robust functional ... research tool for the development of T-cell based immunotherapies, the study of the ...
Breaking Biology News(10 mins):
(Date:8/17/2018)... ... August 16, 2018 , ... KCAS Bioanalytical and Biomarker ... expansion of their team. Dr. Dawn Dufield, Ph.D., joins KCAS as Director of ... LC-MS/MS group that will specialize in developing quantitative LC-MS/MS assays for biopharma molecules. ...
(Date:8/17/2018)... ... August 17, 2018 , ... ... and Environmental Repositories (ISBER) is pleased to announce the release of the Russian ... publication, originally released in January 2018, is a practice-changing publication aimed at advancing ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... treating opioid use disorder. BUP is often prescribed as a sublingual co-formulation with ... , In this webinar, participants will learn from a review of the pharmacokinetics ...
(Date:8/11/2018)... ... August 10, 2018 , ... Researchers performing pressurized NMR or EPR experiments face ... Protection Chamber for High-Pressure NMR & EPR by Wilmad-LabGlass – SP Scienceware shields ... , High-pressure experiments have significantly grown in popularity over the last several years. ...
Breaking Biology Technology:
Cached News: