UT Southwestern researcher, colleagues report drug therapy eases chronic depression

DALLAS Oct. 10, 2002 - A team of scientists representing 12 collaborating health-care centers, including UT Southwestern Medical Center at Dallas, have found that antidepressant therapy specifically sertaline hydrochloride, or Zoloft - can enhance the lives of many chronically depressed patients. The team's findings also showed that discontinuing treatment to patients courts relapse and loss of psychosocial skills.

Dr. John Rush, an internationally known depression researcher who is vice chairman of research in psychiatry at UT Southwestern, said the results send a strong message to health maintenance organizations and insurance companies that deny long-term treatment for a disease that affects millions of Americans. The study, reported in the Archives of General Psychiatry, is the first to systematically look at the long-term impact of depression treatment in the lives of patients and the effects of stopping treatment, said Rush, who was an investigator on the study.

"Chronic depression is an enemy that attacks a person's entire life. The disease incapacitates its victim, laying siege to relationships, educational and vocational success, and even the personal experiencing of joy, pleasure or satisfaction," said Rush.

In all, 635 patients with chronic depression completed 12 weeks of short-term treatment. Those who improved on the Zoloft treatment (209) underwent a four-month continuation trial. Ninety-five percent of those patients responded favorably and were randomized to Zoloft or a placebo for an 18-month maintenance trial. The patients taking Zoloft reported improvement rates of 58 percent to 84 percent on tests qualifying psychosocial dynamics such as functioning, attitudes and quality of life. Only 6 percent of the Zoloft patients relapsed into depression while the placebo group's relapse rate was 23 percent.

Study had either chronic major depression or double depression, a low-level depression disease interrupted by occasio

Contact: Ann Harrell
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:

(Date:5/21/2020)... CARY, N.C. (PRWEB) , ... ... ... Solutions , the leading software-as-a-service (SaaS) provider of operations management solutions, today ... new BioMed module provides a cloud-based platform for connecting the people and ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... helps Life Science Manufacturers accurately and easily project contracted liabilities with payers, ... Gross-to-Net models by projecting discounts/rebates to Commercial and Government entities, Copay and ...
(Date:5/6/2020)... ... May 06, 2020 , ... ... http://www.brevitest.com ) will become the latest out-of-state company to partner with ... Harbor. , Brevitest has developed a point-of-care analyzer capable of accurately performing ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 15, 2020 , ... Sentien Biotechnologies, Inc., a ... Richard Ganz as Executive Chairman. Mr. Ganz will continue to lead Sentien’s Board ... as work closely with CEO Brian Miller and Sentien’s management team. , ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. announced the ... and services for use on Microsoft Azure. The customer experience management (CXM) technology ... for a built-for-purpose customer engagement capability to use in their commercial or medical ...
(Date:4/18/2020)... ... April 17, 2020 , ... ... Small Business Innovation Research (SBIR) program to support the expansion of its digital ... the NSF, which conducts a rigorous merit-based review process, adds to NeuroFlow’s ...
Breaking Biology Technology:
Cached News: