HOME >> BIOLOGY >> NEWS
UT Southwestern researchers develop vaccine against deadly bioterrorism toxin ricin

DALLAS Sept. 4, 2002 UT Southwestern Medical Center at Dallas researchers have developed a vaccine in mice against the deadly toxin ricin. Ricin has been used as a biological weapon in many parts of the world.

"Ricin is not only dangerous, but it is also cheap and easy to make," said Dr. Ellen Vitetta, director of the Cancer Immunobiology Center at UT Southwestern and senior author of the study to be published in the Sept. 10 issue of the journal Vaccine.

Large stockpiles of ricin have been found in several countries in the Middle East, Vitetta said. It is a protein produced by castor beans. A single ricin molecule inside a cell shuts down protein synthesis, killing the cell. Ricin can be administered in foods and water or sprayed as an aerosol. A small dose can produce flulike symptoms and result in death in a few days.

Because of its ease of production and high toxicity, ricin has found its way into the arsenals of extremist individuals, groups and governments. Iraq is known to have ricin as part of its biological weapons program, and it is believed that at least one group linked to the terrorist organization al-Qaeda also has experimented with the poison as a weapon. Domestically, several individuals have been arrested and convicted of ricin possession in recent years under the 1989 Biological Weapons Antiterrorism Act.

In creating the new vaccine, UT Southwestern researchers, led by Vitetta, mutated the DNA encoding the active A chain of the toxin. They took out the site that inhibits protein synthesis, as well as the site responsible for inducing vascular leak. The latter was identified by Vitetta's group several years ago in its ongoing efforts to produce safer immunotoxins containing the A chain. Immunotoxins are anti-cancer drugs that have been used by Vitetta and her colleagues in more than 200 cancer patients. The new recombinant A chain induces a protective immune response in mice and protects them against very high dose
'"/>

Contact: Wayne Carter
wayne.carter@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
4-Sep-2002


Page: 1 2 3

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/30/2019)... Maine (PRWEB) , ... October 29, 2019 , ... ... and calibration verification kits, for SIEMENS ATELLICA® analyzers, Order Numbers 701sa & 704sa. ... MG, NA, PHOS, UA, UTP, and UUN. , Each VALIDATE® kit, liquid, ready-to-use, ...
(Date:10/30/2019)... ... October 30, 2019 , ... Amberdata Inc., the leading blockchain ... Fenbushi Capital, DF Capital, Rising Tide Fund, and HWVP. The new investment ... accelerate its position as the leading data provider of institutional-grade blockchain and cryptoasset ...
(Date:10/29/2019)... ... October 29, 2019 , ... ... for biopharmaceutical R&D, today announced that Octapharma, one of the world’s largest ... support the development and manufacturing of therapeutic proteins addressing severe diseases in ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global leader ... announces that the U.S. Food and Drug Administration (FDA) has granted the company ... relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia continues ...
(Date:10/3/2019)... ... October 01, 2019 , ... Today Cereset®, the ... the midway point of its randomized research trial for individuals with persisting symptoms ... the efficacy of a non-invasive technology which compares tones delivered to a subject’s ...
(Date:10/3/2019)... ... October 02, 2019 , ... Today marked ... that is enabling clinical program outsourcing success by cultivating radical improvements in leadership, ... biotech veteran executive Brenda Reese, phaseUP™ brings clients deep, broad and unique expertise ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and ... run by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of ... NHS by providing support to develop and deploy solutions to the most pressing challenges ...
Breaking Biology Technology:
Cached News: