HOME >> BIOLOGY >> NEWS
UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases

DALLAS March 15, 2004 Researchers at UT Southwestern Medical Center at Dallas have uncovered a link between two cyst-forming diseases that affect the kidneys, a finding that could lead to treatments for both a rare form of diabetes and a common kidney disease.

"We discovered that the formation of kidney cysts in both maturity-onset diabetes of the young type 5 (MODY5) and autosomal recessive polycystic disease is related to the same gene abnormality. It was a surprise to find this link, as it was not suspected that these two diseases were linked together," said Dr. Peter Igarashi, chief of nephrology at UT Southwestern and senior author of the study, which appears in today's issue of The Journal of Clinical Investigation.

"This finding provides a framework for further investigation. The goal is to understand disease mechanisms, and any time you can find a link between two diseases, it provides an opportunity to better understand the mechanisms involved," Dr. Igarashi said.

MODY5 is a rare inherited form of diabetes caused by mutations of HNF-1, a protein that regulates gene expression. The disease is associated with congenital abnormalities of the kidneys, a condition resulting in large, fluid-filled cysts that lead to kidney failure.

Since it is largely unknown what triggers these cysts to form, Dr. Igarashi and his colleagues used a mouse model to express a mutant form of HNF-1 similar to the form in humans with MODY5. These mice also developed kidney cysts and eventually experienced kidney failure.

The researchers then looked for changes in the expression of other genes involved in cyst formation. Surprisingly, they found the expression of the PKHD1 gene was markedly decreased in the mutated mice. Mutations of PKHD1 cause autosomal recessive polycystic kidney disease, a common genetic cystic disease that affects between one in 10,000 to 40,000 babies and is often fatal in the first month of life. In addition, they found
'"/>

Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Mar-2004


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern research halts narcolepsy symptoms
11. UT Southwestern researchers identify gene as essential for vascular smooth muscle development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... , ... June 24, 2020 , ... ... enterprise software and software-driven clinical data services that accelerate drug development, is collaborating ... selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative ... to support testing operations in the fight against the COVID-19 pandemic in Zambia. ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... COLLEGE STATION, Texas (PRWEB) , ... July 29, ... ... pre-qualified cleanroom solutions today announced the launch of its new tagline, “BUILDING FOR ... within the biopharmaceutical industry and around the globe, requiring fast track capacity to ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
Breaking Biology Technology:
Cached News: