UT Southwestern researchers engineer cells that may hold key to treating inflammatory diseases

DALLAS - August 4, 1999 - Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

The research, reported in this month's issue of Nature Medicine, involved the molecular engineering of cells in mice - a procedure that could eventually lead to the prevention and treatment of inflammatory diseases such as rheumatoid arthritis.

"What we did was to change the concept entirely. We tried to convert dendritic cells (which signal for an immune response) into cells that deliver death signals instead of activation signals," said Dr. Akira Takashima, the Thomas L. Shields, M.D., Professor in Dermatology.

Dendritic cells are specialized white blood cells that serve an important function within the immune system. Normally they send activation signals to T lymphocytes to begin multiplying and initiate an immune response.

"Sometimes the dendritic cells that can help a person acquire protective immunity are also involved in the induction of harmful immune responses," said Takashima. "There are many diseases, especially inflammatory diseases, where T cells play a pathogenic role."

For example, rheumatoid arthritis is a common inflammatory joint disease believed to be caused by an autoimmune response. Patients' immune systems form antibodies that improperly attack the lining surrounding joints, causing chronic inflammation.

"The next step is to translate our knowledge of dendritic cells and apply this technology into clinical trials for treating the various diseases caused by T cells," Takashima said.

Dr. Hiroyuki Matsue, assistant professor of dermatology at UT Southwestern and primary author of the study, collaborated with Takashima and other researchers from UT Southwestern, including Keiko Matsue, postdoctoral researcher, and Michael Walters, research technician.

National Institutes of Health grants supported the study.


Contact: Ione Echeverria
UT Southwestern Medical Center

Page: 1

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:

(Date:10/10/2019)... ... October 10, 2019 , ... Mindray, a ... attendees of the American Society of Anesthesiologists 2019 Annual Meeting to visit exhibit ... 19-21 in Orlando, Florida, and will provide more than 14,000 healthcare professionals from ...
(Date:10/8/2019)... ... October 07, 2019 , ... ... of imaging modalities such as optical projection tomography, optical coherence tomography, echocardiogram, light ... to generate these data sets inhouse, a lot of research groups struggle with ...
(Date:10/4/2019)... (PRWEB) , ... October 03, 2019 , ... Mount Sinai ... that cells hand down from one generation to the next. In a study published ... modulate the activity of this enzyme, leading to cancers and other diseases. , “DNA ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... ... 2019 , ... Murrieta Genomics , the launch pad for genomic sequencing ... Silicon Valley at a special Life Science showcase event on October 10th, ... JJ Lake Business Center located at 340 E. Middlefield Road in Mountain View, California. ...
(Date:9/30/2019)... ... September 30, 2019 , ... The September 2019 edition ... , is now available online on the company’s global website. The Bridge features ... diffraction, fluorescence and imaging, and presents articles, scientific papers and news reports. ...
(Date:9/24/2019)... ... September 24, 2019 , ... Personalized ... training and site qualification for clinical trial sites and physician investigators. The ... potential clinical trial participants. , Clinical trial sites are currently located in San ...
(Date:9/17/2019)... N.J. (PRWEB) , ... September 17, 2019 , ... ... announced that Julie Delaney, Director, Project and Clinical Supplies Management, Asia Pacific (APAC) ... the One Farrer Hotel, Singapore, on Sept. 25-26, 2019. , On Thursday, Sept. ...
Breaking Biology Technology:
Cached News: