UT Southwestern researchers find leptin turns fat-storing cells into fat-burning cells

DALLAS Feb. 9, 2004 Increasing leptin, a protein involved in regulating body weight, in laboratory animals transforms fat-storing cells into unique fat-burning cells, researchers at UT Southwestern Medical Center at Dallas report. They speculate that these findings could provide "a quick and safe solution" to the obesity problem in humans.

Researchers attribute the change in the cell's structure and function in rats from fat storing to fat-burning to a massive increase in the action of mitochondria, the principal energy source of the cell. The increase in mitochondria, which also led to substantial weight loss in the rats, was found two weeks after researchers injected the leptin gene.

Findings from the study will appear in an upcoming issue of the Proceedings of the National Academy of Sciences and are currently available online.

"This is the first careful examination of the fat cells after leptin therapy," said Dr. Roger Unger, director of the Touchstone Center for Diabetes Research at UT Southwestern, a physician at the Dallas Veterans Affairs Medical Center and the study's senior author. "The structure of the cells changed from the normal appearance of a fat cell to a very novel cell that's really never been seen before. There's no precedent for a cell that appears like this.

"The ability to convert fat cells into fat-burning cells may suggest novel therapeutic strategies for obesity."

Dr. Unger and his collaborators began working on this research in 1996. During the initial phase of the study, Dr. Unger observed that the fat had disappeared in the fat cells, but at that time the researchers could only guess why.

"We predicted this in 1996, but until we showed the increase in mitochondria there was not any proof of what was happening, but there were many clues that the fat was being burned inside the cell," Dr. Unger said.

Collaborating with researchers at the University of Geneva Medical School,

Contact: Amy Shields
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:

(Date:8/7/2020)... Ky. (PRWEB) , ... August 06, 2020 , ... ... selected to participate in the prestigious National STEM Scholar Program, a unique professional ... network building, and project support for middle school science teachers nationwide. , Created ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping healthcare ... manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen ... more than 10 years. Early in the COVID-19 crisis, we identified supply chain ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin ... portfolio with a near term focus on Type 2 diabetes and associated comorbidities. ... across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin will lead ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... for the life sciences and food industries, is pleased to announce that Charles ... Research – Business Development. , Charles is an accomplished and results-driven sales executive ...
Breaking Biology Technology:
Cached News: