HOME >> BIOLOGY >> NEWS
UT Southwestern researchers identify enzyme deficiency responsible for some sudden infant death cases

DALLAS - August 27, 199 - The discovery by UT Southwestern Medical Center at Dallas researchers that an enzyme deficiency is responsible for some infant deaths attributed to Sudden Infant Death Syndrome (SIDS) could lead to new postnatal testing to identify those at risk.

"Our observations suggest that this deficiency is a severe disorder contributing to early infant death," said Dr. Michael J. Bennett, a professor of pathology and pediatrics at UT Southwestern and director of clinical chemistry at Children's Medical Center of Dallas. "The defect is a deficiency in the SCHAD - short-chain L-3-hydroxyacyl coenzyme A dehydrogenase - enzyme."

The findings were published in the July/August issue of Pediatric and Developmental Pathology.

The deficiency occurs during the breakdown of fatty acids derived from fat stores in the body. The body uses these fats as an energy source when its normal energy supply of glucose, which is converted into glycogen, is used up. In the event of fasting, infants tend to exhaust their limited glycogen supply quickly and begin using the stored fat, Bennett said.

The clinical consequences of SCHAD deficiency -- an inborn error of metabolism -- occur when fatty acids from the stored fats enter the liver and fail to generate energy or to produce ketones. Ketones are a vital energy source for the brain because it cannot use fatty acids, unlike the heart and skeletal muscle, which use fat directly.

"In these infants, fat can get into the liver, but it can't be metabolized and released," Bennett said. "Hence infants' brains starve from the deficit of ketones, and they become comatose."

The researchers examined 150 cases for this study. While only 2 percent were due to SCHAD deficiency, the researchers hope their findings will prevent at least a small portion of the unexpected fatalities previously described as SIDS cases by developing immediate postnatal testing that would identify infants with the enzyme deficienc
'"/>

Contact: Jennifer Haigh
jhaigh@mednet.swmed.edu
214-648-3404
UT Southwestern Medical Center
27-Aug-1999


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... ... August 21, 2019 , ... ... line for rapid and low-cost biomanufacturing of complex protein therapeutics, today announced the ... of AbSci's Scientific Advisory Board, Dr. Larimore brings more than 30 years of ...
(Date:8/21/2019)... (PRWEB) , ... August 20, 2019 , ... ... experience for the second time since BioInformatics first fielded the survey in 2016. ... Life Science Customer Experience , from BioInformatics, part of Science and Medicine Group. ...
(Date:8/15/2019)... (PRWEB) , ... August 15, 2019 , ... Deep ... of their Food and Agriculture practice, a new unit dedicated to building 100 companies ... sustainable nutrition, raw materials and supply chains. , Deep Science Ventures was founded ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... ... in chronic diseases, announces today that the U.S. Patent and Trademark Office (USPTO) ... algorithm to rank drug class recommendations for hypertension treatment. , The patent ...
(Date:9/17/2019)... ... September 16, 2019 , ... A new episode of Advancements ... ET. Check local listings for more information on this program. , The show ... company from Singapore dedicated to developing advanced diagnostic technologies for the masses. Viewers ...
(Date:9/11/2019)... ... September 09, 2019 , ... Suvoda ... randomization and drug supply chain management, today announced its new technology partnership with ... industry. , “The integration between Veeva Vault EDC and our IRT will enable ...
(Date:9/9/2019)... , ... September 09, 2019 , ... Visikol CEO Dr. ... that was focused on how best to characterize 3D cell culture models. The inherent ... they are too thick and opaque to image through and therefore traditional wide-field or ...
Breaking Biology Technology:
Cached News: