HOME >> BIOLOGY >> NEWS
UT Southwestern researchers identify gene as essential for vascular smooth muscle development

DALLAS March 11, 2004 Researchers at UT Southwestern Medical Center at Dallas have discovered a major mechanism to explain normal and abnormal smooth muscle growth, a finding that could help in the development of novel therapeutics for disorders like hypertension and asthma.

Their work appears in today's issue of Nature.

Smooth muscle cells are essential for the formation and function of the cardiovascular system, as well as many internal organs such as the stomach, intestine, bladder and uterus. Abnormalities in their growth can cause a wide range of human disorders, including atherosclerosis, hypertension, asthma and leiomyosarcoma (a fatal smooth-muscle cancer). The molecular mechanisms that control smooth muscle cell growth and differentiation, however, have been poorly understood.

"It has long been known that many diseases result from abnormal growth of smooth muscle cells," said Dr. Eric Olson, chairman of molecular biology and senior author of the study. "The new findings are quite exciting because they reveal a previously unknown mechanism that controls the growth and differentiation of smooth muscle cells. Knowing this mechanism, we can think about ways of regulating it to control smooth muscle growth during disease."

Dr. Olson recently discovered a master regulator of smooth muscle development, a protein called myocardin. This regulator turns on smooth muscle genes by interacting with serum response factor (SRF), a widely expressed protein that binds DNA.

In the Nature study, Dr. Olson and his colleagues showed that the ability of myocardin to turn on smooth muscle genes is counteracted by another protein, Elk-1, which prevents myocardin from binding to SRF. When Elk-1 displaces the myocardin from SRF, it triggers smooth muscle cell proliferation, an effect associated with cardiovascular disease.

With these findings, scientists now have important new insights into the cellular mechanisms that control the
'"/>

Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
10-Mar-2004


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 20, 2020 , ... ... for drugs, biologics, cell and gene therapies, and consumer health products, today announced ... will be presenting at the ISCT 2020 Paris Virtual conference, which takes place ...
(Date:5/15/2020)... Md. (PRWEB) , ... May 15, 2020 , ... The ... boutique intellectual property law firm based in Frederick, Maryland and Tysons Corner, Virginia, to ... field of biotechnology and a another in the field of chemistry. The firm is ...
(Date:5/14/2020)... ... May 14, 2020 , ... The annual salary ... found the 2019 average medical sales rep total compensation increased by $12,000 over ... amid the COVID-19 global crisis. , The MedReps 2020 Salary Survey revealed yet ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... ... May 29, 2020 , ... ... device, diagnostics, and animal health markets, has enabled Cytovale, Inc., a medical technology ... and machine learning, to achieve their first patient in (FPI) in just seven ...
(Date:5/26/2020)... ... 2020 , ... Brilliant , the leading smart home control and lighting ... announce a new integration to bring more convenience, simplicity, and security to the smart ... Connect® can now be controlled from Brilliant’s in-wall touchscreen control panels and mobile app. ...
(Date:5/21/2020)... Calif. (PRWEB) , ... May 20, 2020 , ... ... the addition of Simon Prakash, who will serve as the company’s executive vice ... at a time when Exo is disrupting the medical imaging space, bringing more ...
(Date:5/15/2020)... Mass. (PRWEB) , ... May 15, 2020 , ... Sentien ... the appointment of Richard Ganz as Executive Chairman. Mr. Ganz will continue to ... years, as well as work closely with CEO Brian Miller and Sentien’s management team. ...
Breaking Biology Technology:
Cached News: