Their work appears in today's issue of Nature.

Smooth muscle cells are essential for the formation and function of the cardiovascular system, as well as many internal organs such as the stomach, intestine, bladder and uterus. Abnormalities in their growth can cause a wide range of human disorders, including atherosclerosis, hypertension, asthma and leiomyosarcoma (a fatal smooth-muscle cancer). The molecular mechanisms that control smooth muscle cell growth and differentiation, however, have been poorly understood.

"It has long been known that many diseases result from abnormal growth of smooth muscle cells," said Dr. Eric Olson, chairman of molecular biology and senior author of the study. "The new findings are quite exciting because they reveal a previously unknown mechanism that controls the growth and differentiation of smooth muscle cells. Knowing this mechanism, we can think about ways of regulating it to control smooth muscle growth during disease."

Dr. Olson recently discovered a master regulator of smooth muscle development, a protein called myocardin. This regulator turns on smooth muscle genes by interacting with serum response factor (SRF), a widely expressed protein that binds DNA.

In the Nature study, Dr. Olson and his colleagues showed that the ability of myocardin to turn on smooth muscle genes is counteracted by another protein, Elk-1, which prevents myocardin from binding to SRF. When Elk-1 displaces the myocardin from SRF, it triggers smooth muscle cell proliferation, an effect associated with cardiovascular disease.

With these findings, scientists now have important new insights into the cellular mechanisms that control the
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Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
10-Mar-2004