HOME >> BIOLOGY >> NEWS
UT Southwestern researchers reveal mechanisms of smooth-muscle contraction

DALLAS April 5, 2004 Researchers at UT Southwestern Medical Center at Dallas are the first to use genetically engineered mice containing a fluorescent molecule to examine in real time the chemical reactions that result in smooth-muscle contraction.

Smooth muscle, found in the walls of blood vessels and in internal organs such as lungs, stomach and the bladder, contracts as the end result of a series of chemical reactions. In a new study, UT Southwestern researchers report that one set of chemical reactions resulting in the contraction of the smooth-muscle cells is augmented by a second chemical pathway that kicks in when the first pathway is limited.

"Understanding the underlying chemical signals involved in this process may have implications in treating conditions such as hypertension and other smooth muscle related conditions where there is too much contractile activity," said Dr. James Stull, chairman of physiology at UT Southwestern and senior author of the study.

The research appears in an upcoming issue of the Proceedings of the National Academy of Sciences and was to be posted online this week.

Dr. Stull and his colleagues discovered that when one of the chemicals in the primary contraction mechanism a protein called calmodulin is in short supply, a second series of chemical reactions kicks in to take up the slack. The result is that the strength of the contraction of smooth-muscle cells remains robust.

The first step in the primary chemical pathway for muscle contraction is for calcium in the muscle cell to combine with calmodulin. Then, the calcium/calmodulin complex "activates" a protein called myosin light chain kinase (MLCK). If not activated, MLCK cannot transfer phosphate to the motor protein myosin. Myosin needs the phosphate in a process called phosphorylation to initiate contraction in smooth-muscle cells.

When the researchers treated smooth muscle cells from mi
'"/>

Contact: Amanda Siegfried
Amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
5-Apr-2004


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
8. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
9. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
10. UT Southwestern research halts narcolepsy symptoms
11. UT Southwestern researchers identify gene as essential for vascular smooth muscle development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
Breaking Biology Technology:
Cached News: