HOME >> BIOLOGY >> NEWS
UT Southwestern researchers say overdoses of acetaminophen cause most cases of acute liver failure

at 39 percent of cases were from acetaminophen overdose, and they also discovered that 13 percent were from idiosyncratic drug reactions; 12 percent were from viral hepatitis A and B; and 17 percent were of indeterminate cause.

"Acetaminophen is quite safe when taken accordingly to package recommendations," Lee said. "Eighty-three percent of our patients who developed acute liver failure had exceeded the daily maximum recommended dose of four grams."

While 68 percent of patients with acute liver failure related to acetaminophen overdose recovered with supportive care and 6 percent required transplantation, only 25 percent of patients with idiosyncratic drug reactions recovered and more than 50 percent required transplants once their nervous systems were damaged by liver function failure.

In 1997, Lee formed a consortium of liver centers, called the Acute Liver Failure Study Group, to increase research in this area. The scientific collaboration has made it possible for investigators to study the disease in greater depth.

Two former UT Southwestern researchers Drs. George Ostapowicz and Frank Schiodt also contributed to the study. Other collaborators are from Baylor University Medical Center; the Mayo Clinic; Gold Coast Hospital in Southport, Australia; Northwestern University; and the universities of Michigan, Washington, California-Los Angeles, California-San Francisco, Nebraska, and Pittsburgh.


'"/>

Contact: Susan Morrison
Susan.Morrison@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
16-Dec-2002


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:
(Date:3/12/2015)... 12, 2015 IriTech, a leading iris based ... the Texas Instruments Design Network, announced today that the ... its IriShield USB MK2120U device during a launching event ... distribution. The iris scanner is manufactured ... in India through its Indian ...
(Date:3/11/2015)...   The Sync Project™ today announced ... and harness music to improve health. The platform ... measurements of physiology, enabling the study of the ... populations. It is designed for medical and health ... studies and accelerate the discovery of the clinical ...
(Date:3/5/2015)... 5, 2015 In Brazil , ... already using these solutions and 42 percent planning to invest ... approximately 25 percent of the companies will be investing in ... majority of companies in the region are currently opting for ... model will command significant attention in the coming years. This ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
(Date:3/27/2015)... UK (PRWEB) March 27, 2015 The ... the back of the recession and high prices in ... market has recovered and keeps on gaining momentum now. ... NPK stands at more than 100,000 thousand tonnes. No ... years. Meantime, the global capacity rocketed during 2012-2013, registering ...
(Date:3/27/2015)... , March 27, 2015   SurePure, ... liquid photopurification, announced today that the Company has ... the continued trading of SurePure ("SURP") securities on ... marketplace for entrepreneurial and development stage companies. ... introduced standards and eligibility requirements designed to improve ...
(Date:3/27/2015)... March 27, 2015 WuXi PharmaTech (Cayman) ... R&D capability and technology platform company serving the ... today that an Investigational New Drug (IND) application ... rheumatoid arthritis has been accepted for review by ... In September 2012, MedImmune, the global ...
(Date:3/26/2015)... 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ... advanced testing solutions for the detection of foodborne ... three months and full year ended December 31, ... for the quarter ended December 31, 2014 was ... quarter of 2013 and $1.5 million for the ...
Breaking Biology Technology:World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7
Cached News: