UT Southwestern researchers say overdoses of acetaminophen cause most cases of acute liver failure

at 39 percent of cases were from acetaminophen overdose, and they also discovered that 13 percent were from idiosyncratic drug reactions; 12 percent were from viral hepatitis A and B; and 17 percent were of indeterminate cause.

"Acetaminophen is quite safe when taken accordingly to package recommendations," Lee said. "Eighty-three percent of our patients who developed acute liver failure had exceeded the daily maximum recommended dose of four grams."

While 68 percent of patients with acute liver failure related to acetaminophen overdose recovered with supportive care and 6 percent required transplantation, only 25 percent of patients with idiosyncratic drug reactions recovered and more than 50 percent required transplants once their nervous systems were damaged by liver function failure.

In 1997, Lee formed a consortium of liver centers, called the Acute Liver Failure Study Group, to increase research in this area. The scientific collaboration has made it possible for investigators to study the disease in greater depth.

Two former UT Southwestern researchers Drs. George Ostapowicz and Frank Schiodt also contributed to the study. Other collaborators are from Baylor University Medical Center; the Mayo Clinic; Gold Coast Hospital in Southport, Australia; Northwestern University; and the universities of Michigan, Washington, California-Los Angeles, California-San Francisco, Nebraska, and Pittsburgh.


Contact: Susan Morrison
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. UT Southwestern biochemist honored with NIH Directors Pioneer Award
3. RSV can increase the risk of asthma, UT Southwestern researchers find
4. Searle Scholars program awards $240,000 to UT Southwestern researcher
5. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
8. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
9. UT Southwestern researchers cite recent advances in underlying causes of rare body-fat disorders
10. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases
11. UT Southwestern research halts narcolepsy symptoms

Post Your Comments:

(Date:6/22/2016)... , June 22, 2016 On Monday, the ... to industry to share solutions for the Biometric Exit ... Customs and Border Protection (CBP), explains that CBP intends ... departing the United States , in ... to defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
Breaking Biology Technology:
Cached News: