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UT Southwestern scientist explores caffeine-signaling activity in brain function

DALLAS Aug. 29, 2002 Every morning millions of Americans reach for the world's most popular drug to help them start their day.

"That drug is caffeine," said Dr. James Bibb, assistant professor of psychiatry at UT Southwestern Medical Center at Dallas. Bibb is one of the authors of a new report explaining how caffeine exerts its stimulatory effect by altering the biochemistry of the brain. The findings appear in an August issue of Nature.

"Caffeine is the most frequently self-administered drug in recreational use worldwide today," Bibb said. "And yet we know little about how caffeine works in the brain, whether with the kick from a double espresso or small jolts from tea or cola. We do know it is rewarding, can enhance cognition and performance, and induce dependence at the same time."

Bibb said most people would never consider that the effects of their morning coffee would have any similarities to those of cocaine, long known to be a powerful and dangerous recreational drug. But research is showing that the two stimulants similarly alter a specific signaling activity within the brain.

The researchers involved in the Nature paper used genetically altered mice lacking DARPP-32, a protein known to play a role in drug addiction, to explore questions about caffeine's stimulant effects. Normal mice given a 7.5 milligram/kilogram dose of caffeine showed a dramatic increase in long-range (locomotion) and short-range (motility) movements for as long as 100 minutes. This amount of caffeine is the equivalent of about three cups of coffee for a person weighing 160 pounds. When scientists gave the mice lacking DARPP-32 the same dose, it had little effect. Only by doubling the dose to 15 mg/kg were researchers able to overcome the knockout effect of gene deletion.

Bibb said these results were similar to those of his previous studies that explored the same biochemical pathways activated by cocaine.

Bibb explained that it has be
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Contact: Ann Harrell
Ann.Harrell@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
29-Aug-2002


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