HOME >> BIOLOGY >> NEWS
UVa researchers describe method of protecting chromosomes during cell division

CHARLOTTESVILLE, Va., Mar. 4 One hallmark of most cancer cells is that they have the incorrect number of chromosomes, a state called aneuploidy. Now, researchers at the University of Virginia Health System, writing in a recent issue of the journal Current Biology, think they know how cells protect themselves from aneuploidy when they divide in a process known as mitosis. "During mitosis, the cell divides replicated chromosomes to two daughter cells. We are studying a mitotic system that ensures that each cell receives the right number of chromosomes," said article co-author Todd Stukenberg, assistant professor of biochemistry and molecular genetics at U.Va.

To function effectively, a human cell must have one copy of 46 different chromosomes, each containing two exact copies of a long DNA strand packaged into two sister chromatids. When a cell divides, it forms a spindle made up of thin polymers called microtubules extending from opposing sides of the cell.

During division, however, the cell is faced with a monumental sorting problem since all chromosomes look alike. So, nature has devised a solution microtubules from one side of the cell must bind one chromatid, while microtubules from the other side bind the other. The cell then uses these microtubule connections to pull the two sister chromatids to opposite sides of the cell, and the cell is then cleaved between the two DNA masses. Aneuploidy may occur when this process goes awry and microtubules from opposite sides of the cell bind the same chromatid, which becomes stuck since it is pulled in both directions, Stukenberg said.

According to the study, researchers at the U.Va.'s Department of Biochemisty and Molecular Genetics, working with colleagues in U.Va.'s Department of Chemistry, have uncovered a mechanism that could correct these improper attachments proteins that release improper microtubule attachments. A protein called Aurora B loads a substance called MCAK (mi
'"/>

Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
4-Mar-2004


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... antibody development services, today announced that the company has received ISO9001:2015 certification ... pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation ... binding assays (LBA) have dominated this area. However, the use of mass spectrometry in ... This now necessitates the question “How do you choose which approach to use (LBA ...
(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online post, ... Dr. James L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company ... on June 16 that starting July 5 it would begin offering free ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... of Technology (MIT) has expanded the company’s exclusive license to include clinical ... the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien ... announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical ... development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an Emeritus ...
(Date:7/7/2020)... BOSTON (PRWEB) , ... July 06, 2020 , ... ... Innovative Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of ... Since 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... procured purchasing contracts to its membership, recently named BioFit Engineered Products ... the opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at ...
Breaking Biology Technology:
Cached News: