HOME >> BIOLOGY >> NEWS
UW-Madison scientists return to rat as biomedical research tool

MADISON - Ever a favorite of biologists because of its record as a model to understand ailments like diabetes and cancer, the lab rat lost its luster as a research tool during the past decade because it defied attempts to manipulate its genome in a prescribed way.

Now, using a novel combination of tried-and-true techniques, scientists have created the first "knockout" rats, specifically rats whose genomes have been stripped of genes that suppress breast cancer. The development, reported today (May 19) by a team of scientists from the University of Wisconsin-Madison in online editions of the journal Nature Biotechnology, promises to restore the rat to biomedical prominence.

"People have tried for more than 10 years to produce a knockout rat," says Michael N. Gould, a professor of oncology at UW-Madison's McArdle Laboratory for Cancer Research and in whose laboratory the work was conducted.

For 100 years, he explains, the rat was the model of choice for many biomedical scientists. But a decade ago, when knockout technology was first widely deployed in the mouse, the sturdy rat was dethroned. Researchers rushed to take advantage of the biomedical possibilities of an animal model whose genome could be manipulated at will, adding or subtracting genes to gain surprising insight into a host of diseases and potential treatments.

The rat, says Gould, had been "compromised by the lack of a full genetic toolbox. Over the last 10 years, the government and drug companies have invested a lot in bringing the rat up to speed. But one of the last major elusive tools for our toolbox was the ability to knock out genes."

The ability to add or subtract genes to an animal's genome lends powerful insight into the basic mechanisms of disease. New methods of disease prevention and treatment in humans, as well as a better basic understanding of development, physiology and pathology have resulted from the ability of scientists to manipulate genes in liv
'"/>

Contact: Michael Gould
gould@oncology.wisc.edu
608-263-6615
University of Wisconsin-Madison
18-May-2003


Page: 1 2 3

Related biology news :

1. UW-Madison scientists find a key to cell division
2. National nanotech expert to address UW-Madison conference
3. UW-Madison researchers identify key to cancer cell mobility
4. UW-Madison team develops technique to create flu viruses
5. DNA lends scientists a hand, revealing new chemical reactions
6. Conference at UH opens doors for new scientists, engineers
7. Wisconsin scientists develop quick botox test
8. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
9. Alaska scientists find Arctic tundra yields surprising carbon loss
10. UAF scientists discover new marine habitat in Alaska
11. Information system to help scientists analyze mechanisms of social behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOG´s ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , ... Well Made Simple," and 23andMe , the leading ... better food choices.  Zipongo can now provide customers with ... preferences, health goals and biometrics, but also genetic markers ... choices. Zipongo,s personalized food decision support platform ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics ... The move comes after the company changed focus to making analytical tools for ... and our new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart ...
(Date:4/19/2017)... , ... April 19, 2017 , ... ... which makes educational webinars accessible to novices as well as experienced users, ... variables of commonly performed coagulation screening tests. , Hemostasis testing quality is ...
(Date:4/19/2017)... 19, 2017 Veracyte, Inc. ... it will report its first quarter 2017 financial ... 2017. Following the announcement, Veracyte,s management will host a live ... discuss the company,s financial results and business progress. ... may be accessed by visiting Veracyte,s website at  http://investor.veracyte.com . ...
(Date:4/18/2017)... Texas (PRWEB) , ... April 18, 2017 , ... For ... Research Associates, co-members in the VaxCorps vaccine consortium, were named one of the top ... finalist since the inception of this category; winning the award four times previously, and ...
Breaking Biology Technology:
Cached News: