The finding is novel because most bacteria use sugars and other carbohydrates to grow, says Dr. Jonathan Olson, assistant professor of microbiology at NC State. The human pathogen Helicobacter pylori does not.

"No one has ever suspected hydrogen to be an energy source for pathogens," Olson said. "Now we have a whole new target for antibiotics for this particular bacteria."

The research is described in a paper published in the Friday, Nov. 29 edition of Science.

The study was performed at the University of Georgia, where Olson was a member of the research faculty before joining the microbiology faculty at NC State this summer. Dr. Robert J. Maier, a microbiologist at the University of Georgia, is a co-author of the paper. The work was supported by the Georgia Research Alliance.

H. pylori is only found in humans, Olson says. The bacteria infects greater than 50 percent of the world's population, and persists until it is treated. If left untreated, the bacteria can give rise to ulcers and two different kinds of cancer.

H. pylori contains an enzyme - hydrogenase - that uses hydrogen as an energy source. "If we were to develop a drug to inhibit the hydrogenase enzyme, we could eradicate ulcers in humans," Olson says.

Using mice as a model, the scientists discovered that mice stomachs contained more than enough hydrogen to support the growth of H. pylori. The study showed that mice stomachs contained 10 to 50 times more hydrogen than the bacteria needs to grow.

Moreover, when the scientists created a mutant strain of H. pylori without hydrogenase, only 24 percent of these mutants colonized in mice, as opposed to 100 percent of the
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Contact: Dr. Jonathan Olson
jonathan_olson@ncsu.edu
919-515-7860
North Carolina State University
2-Dec-2002