HOME >> BIOLOGY >> NEWS
Uncertainty in clinical tests raises health care costs

Small measurement uncertainties in clinical laboratory tests can add large amounts to health care costs, according to a newly released study commissioned by the National Institute of Standards and Technology (NIST).

The study,* conducted by RTI International (Research Triangle Park, N.C.) and the Mayo Clinic (Rochester, Minn.), estimates that calibration errors in measurements of calcium levels in blood may add between $60 million and $199 million to U.S. health care costs annually. High calcium levels can be a symptom of diseases such as cancer and thyroid disorders.

Accurate measurements are critical because calcium levels in healthy people fall within a narrow range, between 8.9 to 10.1 milligrams (mg) per deciliter (dL). Through interviews with laboratory managers and equipment manufacturers, the researchers estimated that results for up to 15 percent of calcium laboratory tests contain calibration errors of between 0.1 and 0.5 mg per dL. This means that some results that fall in the center of the "normal" range, say 9.7 mg/dL, may in fact be for patient samples with elevated calcium, defined as 10.2 mg/dL and above. At the same time, patients with measured values above the threshold, but who actually have normal calcium levels, may receive unnecessary follow-up procedures such as hormone measurements and chest X-rays.

The study analyzed data for more than 89,000 patients receiving serum calcium tests at the Mayo Clinic from 1998 to 1999. It found that calibration errors added between $8 and $89 per patient to the health care costs of approximately 3.55 million patients.

Major sources of calibration error include differences in analysis methods used by different laboratory instruments, lot-to-lot variations in calibration materials, and lack of "traceability" between secondary reference materials and primary standards such as Standard Reference Materials produced by NIST.


'"/>

Contact: Laura Ost
laura.ost@nist.gov
301-975-4034
National Institute of Standards and Technology (NIST)
7-May-2004


Page: 1

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
3. Innovative ceramic-on-metal hip replacements to undergo clinical trials
4. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
5. Warren Pharmaceuticals publishes results of preclinical evaluation
6. Creation of the UK Clinical Research Collaboration will boost clinical trials in UK
7. Scientists characterize new breast tumor subtypes with poor clinical outcomes
8. Vanderbilts John Oates wins clinical research award
9. Germany starts clinical development of a new tuberculosis vaccine
10. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
11. Genetic profile, not clinical appearance, to determine tumor treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/3/2018)... ... November 01, 2018 , ... The Conference Forum ... held February 6-8, 2019 at the Crowne Plaza Times Square in New York ... session is Genentech’s Global Franchise Leader in Cancer Immunotherapy Biomarkers and IO360° Plenary ...
(Date:11/3/2018)... ... , ... Karius , the leading infectious disease genomics company, is offering ... pediatric patients. One grant of up to $50,000 will be awarded to a research ... In addition to the funding, Karius will cover the cost of sequencing a limited ...
(Date:11/3/2018)... ... , ... As 2018 comes to a close, significant changes to medical device ... for manufacturers worldwide. To mark World Quality Day this month, Boulder iQ ... may sound far off, the May 26 deadline transition deadline that year for the ...
Breaking Biology News(10 mins):
(Date:11/9/2018)... FRANCISCO (PRWEB) , ... November 08, 2018 , ... ... of Dr. Pablo Valenzuela, PhD, co-Founder, Chief Executive Officer and President of Andes ... doctors from around the world, Dr. Valenzuela brings to uBiome expertise on the ...
(Date:11/7/2018)... ... November 07, 2018 , ... ... a campaign to increase awareness of the adult tissue stem cell counting problem ... of November, the company is intensifying this effort with new educational publications and ...
(Date:11/5/2018)... ... 2018 , ... Frederick National Laboratory for Cancer Research is ... research and education in the Frederick County area. , Frederick Center for ... STEM-based undergraduate and graduate degree and certificate programs offered by partnering colleges or ...
(Date:11/5/2018)... ... November 05, 2018 , ... 2Blades has completed a ... (TAL) effector code technology for applications in advancing research in epigenetic technology. ... its discovery in 2009, the efficacy of TAL effector-based DNA targeting has been ...
Breaking Biology Technology:
Cached News: