HOME >> BIOLOGY >> NEWS
Understanding DNA damage: New study suggests environment surrounding DNA plays key role in controlling charge transport

The environment surrounding DNA in living cells plays a surprisingly important role in regulating the movement of electronic charge through the life-coding molecule, suggests a paper to be published October 19 in the journal Science. The work could lead to a better understanding of how DNA is damaged by oxidative processes and offer clues to potential DNA applications in nanotechnology.

Based on experimental data, computer-based molecular dynamics simulations and complex electronic structure calculations, the paper is the first to describe how sodium ions could control the migration of electron holes also known as radical cations through DNA. The electron holes, positively charged locations in the DNA structure, are created by normal cellular oxidation processes and everyday events such as exposure to sunlight. Migrating through the DNA to distances up to 30 nanometers away from their site of origin, the electron holes ultimately reach certain sites where they may initiate reactions that can damage the genetic coding.

"Our paper presents a new way of thinking about what controls electrical charge transport in DNA," said Gary Schuster, a professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology and dean of its College of Sciences. "It is the motions of the water molecules, the sodium ions, the backbone of the DNA and the bases of the DNA that altogether control the movement of charge in the DNA. It's clear that we must consider both the DNA and its environment."

Underlying the charge migration mechanism unveiled in this study are two physical principles: (1) like electrical charges electrostatically repel one another, an
'"/>

Contact: John Toon
john.toon@edi.gatech.edu
404-894-6986
Georgia Institute of Technology Research News
18-Oct-2001


Page: 1 2 3 4

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/9/2018)... ... 08, 2018 , ... Boekel Scientific launches a new programmable ... dry bath incubators are used in laboratories worldwide for controlling and maintaining sample ... heating blocks, Boekel Scientific used the same interface design as their recently launched ...
(Date:11/7/2018)... ... November 07, 2018 , ... uBiome, the leader in microbial ... Biosciences Program within the Department of Medicine, University of Colorado, Denver, to its ... the world, Dr. Lozupone will bring to uBiome an expertise on the factors ...
(Date:11/7/2018)... Va. (PRWEB) , ... November 07, 2018 , ... ... today that Barb Geiger, a senior Clinical Operations professional with extensive experience in ... development in the US, Australia, Latin America, Europe, and Asia, has joined the ...
Breaking Biology News(10 mins):
(Date:11/6/2018)... ... November 06, 2018 , ... Crucial ... trial data collection and management. TrialKit ™, an eClinical platform, has incorporated ... can quickly and easily sign in to the app via facial recognition or ...
(Date:11/5/2018)... , ... November 05, 2018 , ... ... live educational support for healthcare professionals through its website, http://www.glycomark.com , as ... a live chat and video option via the website in November from 9 ...
(Date:11/3/2018)... ... ... Triangle Insights Group, a premier life sciences consulting firm, announced today that it ... United States, appearing on this year’s Inc. 5000 list. Since its inception in ... the previous three years. , Separately, Triangle Insights was also ranked on Consulting ...
(Date:10/31/2018)... POWAY, Calif. (PRWEB) , ... October 30, 2018 , ... Pippa Rose is a young ... was around one year old, Pippa suffered a partial tear to the cruciate ligament in ... unable to run or go on walks. Kinsley reported that it broke her heart ...
Breaking Biology Technology:
Cached News: