HOME >> BIOLOGY >> NEWS
Understanding acetaminophen poisoning

HOUSTON -- (Oct. 11, 2002) -- A protein known as CAR (constitutive androstane receptor) has been shown to regulate liver toxicity caused by the common pain-reliever acetaminophen in studies that point the way to new treatment for poisoning with similar compounds, said scientists at Baylor College of Medicine in today's issue of the journal Science.

Acetaminophen is found in Tylenol and many other medications. Just last month, advisors to the U.S. Food and Drug Administration urged the agency to require a stronger warning label on such products.

"Our work explains an important, but unexpected, component of acetaminophen toxicity and adds a new mechanism to the process. It also suggests a new approach to treating hepatotoxicity," said Dr. David D. Moore, professor of molecular and cell biology at Baylor College of Medicine.

Others involved in the Baylor studies were Jun Zhang, a graduate student, and Drs. Wendong Huang, Steven S. Chua and Ping Wei. When a person takes acetaminophen, the liver produces small amounts of a potentially harmful compound called NAPQI (N-acetyl-p-benzoquinone imine). Normally, the liver uses another chemical called glutathione to quickly neutralize NAPQI.

"The problem occurs when you run out of glutathione," said Moore.

An overdose of acetaminophen can cause depletion of glutathione and land a person in the hospital. "Acetaminophen toxicity is the number one cause of hospital admission for liver failure in the United States," he said.

CAR is a receptor that regulates the response of the liver to drugs and other foreign compounds. When it is activated, the liver increases its ability to modify such compounds and eliminate them from the body. This is normally a protective response. In some cases, however, it can also result in harmful effects, for example by increasing the production of toxic byproducts like NAPQI.

Using a mouse bred to lack CAR, Moore and his co-
'"/>

Contact: Lori Williams
loriw@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
10-Oct-2002


Page: 1 2

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding our ape cousins: chimpanzee genetics may shed light on human diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2019)... ... May 01, 2019 , ... uBiome, the ... John Rakow, the Company’s General Counsel, as Interim Chief Executive Officer of uBiome, ... currently on administrative leave. There will also be an independent investigation into uBiome’s ...
(Date:4/25/2019)... ... April 23, 2019 , ... Leak Detection Associates, ... Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is pleased to announce the ... New Jersey. The new facility was custom designed to meet enhanced manufacturing capabilities ...
(Date:4/25/2019)... Va. (PRWEB) , ... April 24, 2019 , ... NDA ... biostatistician with more than 20 years of experience in the development of drug and ... Expert Consultant. , Prior to joining NDA Partners, Dr. Maddala served as Vice ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... April 24, 2019 , ... ... for sales and service organizations, today announced global availability of Inference Studio’s ... and enterprises of all sizes to harness the power of Google’s Contact ...
(Date:4/16/2019)... SAN ANTONIO (PRWEB) , ... April 16, 2019 ... ... biometrics-based human identification systems, applications, and technology, today announced that Bank South Pacific ... through a competitive RFP process. The bank awarded Fulcrum a contract to deliver ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... technology leaders, have locked into multiple agreements to help companies advance their ... regenerative medicine industry, ranging from synthetic biology companies that are gene editing ...
(Date:4/9/2019)... ... 09, 2019 , ... Sonny Bar Lisa, or Sonny for short, is a ... After a series of diagnostics, an MRI was performed which revealed Sonny had ... injury and found that VetStem Regenerative Cell Therapy may be a treatment ...
Breaking Biology Technology:
Cached News: