HOME >> BIOLOGY >> NEWS
Understanding celiac disease

Two separate research studies published in the September issue of Immunity provide significant new details about why immune cells attack the body's own healthy tissues in response to a harmless substance that the immune system mistakenly perceives as a threat. The results are likely to further research efforts designed to combat and hopefully prevent autoimmune disorders like celiac disease.

Celiac disease is characterized by abnormalities of the small intestine that interfere with absorption of nutrients from food. When people with celiac disease eat foods containing gluten, a major protein in wheat, rye, and barley products, their immune system attacks and damages the lining of the small intestine. Development of this disease has been linked to the transformation of normal immune cells, called cytotoxic T lymphocytes (CTLs), that normally protect the body from ingested pathogens into renegade lymphokine-activated killer (LAK) cells that harm the intestinal lining. However, the processes contributing to active destruction of healthy tissue are not well understood.

A research study headed by Dr. Bana Jabri from the Department of Pathology at the University of Chicago examined a receptor on CTL cells called NKG2D that can be activated by stress-induced chemicals and has been linked to tissue damage. The researchers found that the immune stimulator IL15 induces a series of biochemical changes in the NKG2D signaling pathway that converts CTL cells into LAK cells in cells grown in the laboratory and in patients with celiac disease. "These findings may provide the basis for novel therapeutic approaches in celiac disease aiming at suppressing uncontrolled CTL activation and conversion into LAK by blocking IL15 or NKG2D," suggests Dr. Jabri.

A second study led by Dr. Sophie Caillat-Zucman from Equipe Avenir-Inserm in Paris, France demonstrated that MICA, a molecule that interacts with NKG2D on CTL cells, is present in elevated amounts in the cells
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
14-Sep-2004


Page: 1 2

Related biology news :

1. Understanding nutrition labels can lead to healthier eating
2. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
3. Understanding urinary tract infections
4. Salk news: Understanding organ placement
5. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
6. Understanding the impact of genetic technology
7. Salk news: Understanding gene function
8. Understanding obesity: New research examines how hunger signals work in the brain
9. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
10. Understanding acetaminophen poisoning
11. Understanding our ape cousins: chimpanzee genetics may shed light on human diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... -- This year,s edition of the Inc. 5000 features a now-familiar name: BioPoint ... made the list for the third year in a row. Now in ... based on a set of quantitative metrics. In addition, BioPoint was also ... the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... pharmaceutical and biotherapeutics development, announces the launch of the new NHS Agile ... gain kinetic binding data for a wide range of molecules, including small and ...
(Date:8/15/2017)... New York, NY (PRWEB) , ... August 15, 2017 , ... ... for the first time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming ... to be held February 7-9, 2018, at The Roosevelt Hotel in New York City. ...
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, ... USB or PCI Express, announced the release of SYZYGY™, a new open standard ... the need for a compact, low cost, low pin-count, high-performance connectivity solution between ...
Breaking Biology Technology:
Cached News: