HOME >> BIOLOGY >> NEWS
Understanding celiac disease

Two separate research studies published in the September issue of Immunity provide significant new details about why immune cells attack the body's own healthy tissues in response to a harmless substance that the immune system mistakenly perceives as a threat. The results are likely to further research efforts designed to combat and hopefully prevent autoimmune disorders like celiac disease.

Celiac disease is characterized by abnormalities of the small intestine that interfere with absorption of nutrients from food. When people with celiac disease eat foods containing gluten, a major protein in wheat, rye, and barley products, their immune system attacks and damages the lining of the small intestine. Development of this disease has been linked to the transformation of normal immune cells, called cytotoxic T lymphocytes (CTLs), that normally protect the body from ingested pathogens into renegade lymphokine-activated killer (LAK) cells that harm the intestinal lining. However, the processes contributing to active destruction of healthy tissue are not well understood.

A research study headed by Dr. Bana Jabri from the Department of Pathology at the University of Chicago examined a receptor on CTL cells called NKG2D that can be activated by stress-induced chemicals and has been linked to tissue damage. The researchers found that the immune stimulator IL15 induces a series of biochemical changes in the NKG2D signaling pathway that converts CTL cells into LAK cells in cells grown in the laboratory and in patients with celiac disease. "These findings may provide the basis for novel therapeutic approaches in celiac disease aiming at suppressing uncontrolled CTL activation and conversion into LAK by blocking IL15 or NKG2D," suggests Dr. Jabri.

A second study led by Dr. Sophie Caillat-Zucman from Equipe Avenir-Inserm in Paris, France demonstrated that MICA, a molecule that interacts with NKG2D on CTL cells, is present in elevated amounts in the cells
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
14-Sep-2004


Page: 1 2

Related biology news :

1. Understanding nutrition labels can lead to healthier eating
2. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
3. Understanding urinary tract infections
4. Salk news: Understanding organ placement
5. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
6. Understanding the impact of genetic technology
7. Salk news: Understanding gene function
8. Understanding obesity: New research examines how hunger signals work in the brain
9. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
10. Understanding acetaminophen poisoning
11. Understanding our ape cousins: chimpanzee genetics may shed light on human diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... In an ... on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings for ... are collected at medical offices and are shipped to labs throughout the country. Results ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable ... support testing operations in the fight against the COVID-19 pandemic in Zambia. , ...
(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb ... founder and director of stem cell biotechnology company Asymmetrex . Superb Crew decided ... July 5 it would begin offering free tissue stem cell counting at ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... chain validation engineering firm, is making available for free its new white ... incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). In ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management ... reasons it did not take off as quickly as people initially expected, and where ... towards capturing data electronically for clinical trials and then repurposing it for downstream analysis, ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver ... “It’s the only technology of its kind on the market and we were pleased ... the protective capacity of traditional cultured ingredients, creating a natural way to extend the ...
Breaking Biology Technology:
Cached News: