HOME >> BIOLOGY >> NEWS
Understanding key protein in Fragile X syndrome

December 1, 1999 Fragile X syndrome, the most common inherited form of mental retardation, results from a mutation that somehow affects how genetic messages travel from the cell's nucleus to its protein manufacturing apparatus. With the identification of three key molecular actors in that ferrying process, researchers are now bearing in on the cellular mechanisms underlying Fragile X syndrome, and perhaps other causes of mental retardation as well.

For a condition with such a delicate-sounding name, Fragile X syndrome can have powerful effects, ranging from learning disability and hyperactivity to severe mental retardation. Mutations in a gene known as FMR1 produce the disorder, and Stephen Warren, a Howard Hughes Medical Institute (HHMI) investigator at Emory University, has been studying this gene and its corresponding protein, called FMRP, since he and his colleagues first identified them in 1991.

"When we first identified FMRP, it didn't look like any other protein that had been previously identified, so we really didn't know what it did. But by slowly chipping away over the years, we and others have learned a lot about it," said Warren.

For example, Warren's group has determined that FMRP binds to messenger RNA molecules, forming a complex called RNP (ribonucleoprotein particle). They also know that FMRP shuttles between the cell's nucleus and cytoplasm, and that it visits ribosomes, where the genetic code for building proteins is translated. From all this evidence, they speculated that FMRP must somehow be involved in the translation process.

To understand more about FMRP's function in the cell, Warren's group needed to identify the protein's partners in the RNP complex, a feat that had defied conventional protein-purifying techniques. Not to be thwarted, the researchers developed a set of antibodies that allowed them to isolate not only FMRP, but also messenger RNA (mRNA) and at least six other proteins from the complex. Warren, togeth
'"/>

Contact: Joseph Alper
alperj@hhmi.org
720-890-1956
Howard Hughes Medical Institute
29-Nov-1999


Page: 1 2 3

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... At its national board meeting in North ... the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space Technology and ... ARCS Alumni Hall of Fame . ASTER Labs is a technology development ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
(Date:10/10/2017)... ... 10, 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, ... The bold new look is part of a transformation to increase awareness, appeal ... growth period. , It will also expand its service offering from its signature gourmet ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017 SomaGenics ... from the NIH to develop RealSeq®-SC (Single Cell), expected ... for profiling small RNAs (including microRNAs) from single cells ... Program highlights the need to accelerate development of approaches ... "New techniques for measuring levels ...
Breaking Biology Technology:
Cached News: