Understanding tuberous sclerosis

Tuberous sclerosis (TSC) is a prevalent inherited disease that is caused by mutations in either the TSC1 or TSC2 gene. By generating fruit flies deficient in TSC1, researchers from the University of Texas Southwestern Medical Center have been able to determine that TSC1 and TSC2 antagonize insulin signaling and thereby regulate cell growth.

TSC is characterized by the development of benign tumors throughout various bodily organs. Patients often display skin rashes, seizures and mental retardation as a result of these tumors. Although TSC affects 1 in 6000 live births, or 50,000 people in the United States and over one million people worldwide, until relatively recently the chain of biological events linking TSC gene mutation and tumorigenesis has remained unclear.

As published in Genes & Development, Dr. Duojia Pan and Dr. Xinsheng Gao have determined that TSC1 and TSC2 proteins form complexes in cells, and negatively regulate the insulin pathway in Drosophila. In Drosophila the insulin signaling pathway controls cellular growth and organ size through a multi-step enzymatic cascade. Drs. Gao and Pan found that TSC1 and TSC2 act in a parallel pathway, which converges upon the insulin pathway in such a way as to decrease the effect of insulin on promoting cell growth.

Drs. Gao and Pan found that fly cells deficient in TSC1 display increased cell size, as is also sometimes true in tumors derived from human TSC patients. Further delineation of the role of TSC1 and TSC2 in cell growth regulation will provide valuable insight into the mechanism of this disease and direct therapeutic strategies.


Contact: Nora Poppito
please e-mail
Cold Spring Harbor Laboratory

Page: 1

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:

(Date:10/29/2015)... 2015 Daon, a global leader in mobile ... a new version of its IdentityX Platform , ... America have already installed IdentityX v4.0 and ... FIDO UAF certified server component as an ... FIDO features. These customers include some of the largest ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... N.C. , Nov. 24, 2015  Clintrax Global, Inc., a ... North Carolina , today announced that the company has set ... represented a 391% quarter on quarter growth posted for Q3 of ... and Mexico , with the establishment ... in December 2015. --> United Kingdom ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader ... five states to develop and pitch their BIG ideas to improve health and wellness ... competing for votes to win the title of SAP's Teen Innovator, an all-expenses paid ...
(Date:11/24/2015)... , November 24, 2015 SHPG ) ... participate in the Piper Jaffray 27 th Annual Healthcare Conference ... December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ... Chief Financial Officer, will participate in the Piper Jaffray 27 th ... , NY on Tuesday, December 1, 2015, at 8:30 a.m. EST ...
(Date:11/24/2015)... , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... December 29, 2015 at 11:00 a.m. Israel time, ... Tower, 98 Yigal Allon Street, 36 th Floor, Tel ... Eric Paneth and Izhak Tamir to the Board ... Skaliter as external directors; , approval of an amendment to certain ...
Breaking Biology Technology:
Cached News: