HOME >> BIOLOGY >> NEWS
Understanding tuberous sclerosis

Tuberous sclerosis (TSC) is a prevalent inherited disease that is caused by mutations in either the TSC1 or TSC2 gene. By generating fruit flies deficient in TSC1, researchers from the University of Texas Southwestern Medical Center have been able to determine that TSC1 and TSC2 antagonize insulin signaling and thereby regulate cell growth.

TSC is characterized by the development of benign tumors throughout various bodily organs. Patients often display skin rashes, seizures and mental retardation as a result of these tumors. Although TSC affects 1 in 6000 live births, or 50,000 people in the United States and over one million people worldwide, until relatively recently the chain of biological events linking TSC gene mutation and tumorigenesis has remained unclear.

As published in Genes & Development, Dr. Duojia Pan and Dr. Xinsheng Gao have determined that TSC1 and TSC2 proteins form complexes in cells, and negatively regulate the insulin pathway in Drosophila. In Drosophila the insulin signaling pathway controls cellular growth and organ size through a multi-step enzymatic cascade. Drs. Gao and Pan found that TSC1 and TSC2 act in a parallel pathway, which converges upon the insulin pathway in such a way as to decrease the effect of insulin on promoting cell growth.

Drs. Gao and Pan found that fly cells deficient in TSC1 display increased cell size, as is also sometimes true in tumors derived from human TSC patients. Further delineation of the role of TSC1 and TSC2 in cell growth regulation will provide valuable insight into the mechanism of this disease and direct therapeutic strategies.


'"/>

Contact: Nora Poppito
poppito@cshl.org
please e-mail
Cold Spring Harbor Laboratory
1-Jun-2001


Page: 1

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... BADEN-BADEN, Germany , December 15, 2016 /PRNewswire/ ... services provider, today announced an agreement with NuData Security, ... join forces. The partnership will enable clients to focus on ... with local data protection regulation. ... In order to provide a one-stop ...
(Date:12/15/2016)... Dec 15, 2016 ... Research and Markets has announced the addition of ... The report forecasts the global military biometrics market to ... The report has been prepared based on an in-depth market analysis ... its growth prospects over the coming years. The report also includes a ...
(Date:12/15/2016)... Mich. , Dec. 15, 2016  There is ... car doors or starting the engine. Continental will demonstrate ... Las Vegas . Through the combination ... Start and Entry) and biometric elements, the international technology ... of vehicle personalization and authentication. "The integration ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... 2017  ArmaGen, Inc., today announced that it ... chief executive officer, as well as a member ... ArmaGen more than 17 years of executive management ... biotherapeutics and pharmaceuticals. "Mathias is ... and skillset necessary to lead ArmaGen to its ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... organization with services spanning the full spectrum of drug and device development, and ... services to pharma/device companies and clinicians, today announced Verified Clinical Trials ...
(Date:1/18/2017)... ... January 18, 2017 , ... Opal Kelly, a leading ... PCI Express, announced the ZEM5310 USB 3.0 FPGA Module, combining a SuperSpeed USB ... sized form factor suitable for prototyping, testing, and production-ready integration. The ZEM5310 USB ...
(Date:1/18/2017)... ... 2017 , ... Executive search firm Slone Partners proudly supports ... the advancement of the clinical trials segment. Hosted in Miami, this conference brings ... and management. , As executive talent specialists in the industries central to ...
Breaking Biology Technology:
Cached News: