HOME >> BIOLOGY >> NEWS
Understanding tuberous sclerosis

Tuberous sclerosis (TSC) is a prevalent inherited disease that is caused by mutations in either the TSC1 or TSC2 gene. By generating fruit flies deficient in TSC1, researchers from the University of Texas Southwestern Medical Center have been able to determine that TSC1 and TSC2 antagonize insulin signaling and thereby regulate cell growth.

TSC is characterized by the development of benign tumors throughout various bodily organs. Patients often display skin rashes, seizures and mental retardation as a result of these tumors. Although TSC affects 1 in 6000 live births, or 50,000 people in the United States and over one million people worldwide, until relatively recently the chain of biological events linking TSC gene mutation and tumorigenesis has remained unclear.

As published in Genes & Development, Dr. Duojia Pan and Dr. Xinsheng Gao have determined that TSC1 and TSC2 proteins form complexes in cells, and negatively regulate the insulin pathway in Drosophila. In Drosophila the insulin signaling pathway controls cellular growth and organ size through a multi-step enzymatic cascade. Drs. Gao and Pan found that TSC1 and TSC2 act in a parallel pathway, which converges upon the insulin pathway in such a way as to decrease the effect of insulin on promoting cell growth.

Drs. Gao and Pan found that fly cells deficient in TSC1 display increased cell size, as is also sometimes true in tumors derived from human TSC patients. Further delineation of the role of TSC1 and TSC2 in cell growth regulation will provide valuable insight into the mechanism of this disease and direct therapeutic strategies.


'"/>

Contact: Nora Poppito
poppito@cshl.org
please e-mail
Cold Spring Harbor Laboratory
1-Jun-2001


Page: 1

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a complex biological network, a depiction of a system of linkages and ... Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) ...
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer ... that they have entered into a multiyear collaboration to identify and characterize novel ... additional tools for gene editing across all applications. , Under the terms of ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
Breaking Biology Technology:
Cached News: