HOME >> BIOLOGY >> NEWS
Understanding tuberous sclerosis

Tuberous sclerosis (TSC) is a prevalent inherited disease that is caused by mutations in either the TSC1 or TSC2 gene. By generating fruit flies deficient in TSC1, researchers from the University of Texas Southwestern Medical Center have been able to determine that TSC1 and TSC2 antagonize insulin signaling and thereby regulate cell growth.

TSC is characterized by the development of benign tumors throughout various bodily organs. Patients often display skin rashes, seizures and mental retardation as a result of these tumors. Although TSC affects 1 in 6000 live births, or 50,000 people in the United States and over one million people worldwide, until relatively recently the chain of biological events linking TSC gene mutation and tumorigenesis has remained unclear.

As published in Genes & Development, Dr. Duojia Pan and Dr. Xinsheng Gao have determined that TSC1 and TSC2 proteins form complexes in cells, and negatively regulate the insulin pathway in Drosophila. In Drosophila the insulin signaling pathway controls cellular growth and organ size through a multi-step enzymatic cascade. Drs. Gao and Pan found that TSC1 and TSC2 act in a parallel pathway, which converges upon the insulin pathway in such a way as to decrease the effect of insulin on promoting cell growth.

Drs. Gao and Pan found that fly cells deficient in TSC1 display increased cell size, as is also sometimes true in tumors derived from human TSC patients. Further delineation of the role of TSC1 and TSC2 in cell growth regulation will provide valuable insight into the mechanism of this disease and direct therapeutic strategies.


'"/>

Contact: Nora Poppito
poppito@cshl.org
please e-mail
Cold Spring Harbor Laboratory
1-Jun-2001


Page: 1

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Understanding urinary tract infections
5. Salk news: Understanding organ placement
6. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
7. Understanding the impact of genetic technology
8. Salk news: Understanding gene function
9. Understanding obesity: New research examines how hunger signals work in the brain
10. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
11. Understanding acetaminophen poisoning

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Understanding tuberous sclerosis

(Date:4/17/2014)... stem cell therapies to cure a variety of diseases ... based on cell surface markers. Researchers from the Finnish ... highly expressed in a type of stem cells derived ... an article in BioResearch Open Access , a ... article is available free on the BioResearch ...
(Date:4/17/2014)... developed at Sandia National Laboratories and recently licensed to ... cheaper. , Bacillus anthracis , the bacteria ... over the world and can cause serious, and often ... can survive in harsh conditions for decades. In humans, ... skin contact, inhalation of spores or eating contaminated meat. ...
(Date:4/17/2014)... produce hydrogen sulfide in order to properly multiply and ... the Center for Craniofacial Molecular Biology at the Herman ... Shi, principal investigator on the project, said the presence ... flow of calcium ions. The essential ions activate a ... the creation of new bone tissue, and keeps the ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... 15, 2014 Two champions of science, ... sponsorship of an annual competition for middle and high ... to, innovative STEM study. The competition presents students with ... of Engineering Aptitude, Mathematics, and Sciences is a ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
Cached News: