HOME >> BIOLOGY >> NEWS
Understanding urinary tract infections

St. Louis, Jan. 19, 2004 -- Researchers at Washington University School of Medicine in St. Louis and Stanford University have captured time-lapse movies of a urinary tract infection (UTI) in progress, illuminating several new details of how the bacteria E. coli invade cells and gang up to overwhelm the cells' defenses.

The images reveal for the first time that E. coli, which are responsible for 80 to 90 percent of all UTIs, pass through at least four distinct developmental stages during the course of an infection. Researchers hope to further define these stages and use them as guides in the search for new drugs.

The study, to be published this week in the early online edition of the Proceedings of the National Academy of Sciences, also reveals that bacteria will sometimes shift into an inactive state, creating reservoirs of infection within the bladder that might be responsible for some of the recurrent UTIs that plague many women.

To image the bacteria in action through a videomicroscope, researchers made the bacteria glow by adding a phosphorescent green protein. The movies show the bacteria rapidly changing themselves and their interactions with each other to collectively hijack bladder cells and use them as safe havens for replication.

"It just boggles the mind what these bacteria can do, in terms of sensing and responding to their environment and each other," says Scott J. Hultgren, Ph.D., the Helen Lehbrink Stoever Professor of Molecular Microbiology and lead investigator of the study. "This has never been seen before in live host tissue, and parts of this process are probably present in a multitude of different kinds of pathogens."

UTIs, which mainly occur in women, are the second most common type of bacterial infection. Linked to poor hygiene, sexual behavior and migration of intestinal flora, they are believed to cause around $1.6 billion in medical expenses every year in the United States. Scientists estimate half of
'"/>

Contact: Michael C. Purdy
purdym@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
19-Jan-2004


Page: 1 2 3

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Salk news: Understanding organ placement
5. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
6. Understanding the impact of genetic technology
7. Salk news: Understanding gene function
8. Understanding obesity: New research examines how hunger signals work in the brain
9. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
10. Understanding acetaminophen poisoning
11. Understanding our ape cousins: chimpanzee genetics may shed light on human diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. ... awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of ... optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 17, 2020 , ... Commercial ... hangs on pharma’s ability to discover a COVID cure or vaccine, the global economic ... competitive and price pressure is not going away and capturing full value from every ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/7/2020)... ... July 06, 2020 , ... ... from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, ... has hosted an elite awards program, highlighting outstanding examples of how technology innovations ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal ... contracts to its membership, recently named BioFit Engineered Products an Awarded ... to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted pricing ...
Breaking Biology Technology:
Cached News: