HOME >> BIOLOGY >> NEWS
Understanding urinary tract infections

St. Louis, Jan. 19, 2004 -- Researchers at Washington University School of Medicine in St. Louis and Stanford University have captured time-lapse movies of a urinary tract infection (UTI) in progress, illuminating several new details of how the bacteria E. coli invade cells and gang up to overwhelm the cells' defenses.

The images reveal for the first time that E. coli, which are responsible for 80 to 90 percent of all UTIs, pass through at least four distinct developmental stages during the course of an infection. Researchers hope to further define these stages and use them as guides in the search for new drugs.

The study, to be published this week in the early online edition of the Proceedings of the National Academy of Sciences, also reveals that bacteria will sometimes shift into an inactive state, creating reservoirs of infection within the bladder that might be responsible for some of the recurrent UTIs that plague many women.

To image the bacteria in action through a videomicroscope, researchers made the bacteria glow by adding a phosphorescent green protein. The movies show the bacteria rapidly changing themselves and their interactions with each other to collectively hijack bladder cells and use them as safe havens for replication.

"It just boggles the mind what these bacteria can do, in terms of sensing and responding to their environment and each other," says Scott J. Hultgren, Ph.D., the Helen Lehbrink Stoever Professor of Molecular Microbiology and lead investigator of the study. "This has never been seen before in live host tissue, and parts of this process are probably present in a multitude of different kinds of pathogens."

UTIs, which mainly occur in women, are the second most common type of bacterial infection. Linked to poor hygiene, sexual behavior and migration of intestinal flora, they are believed to cause around $1.6 billion in medical expenses every year in the United States. Scientists estimate half of
'"/>

Contact: Michael C. Purdy
purdym@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
19-Jan-2004


Page: 1 2 3

Related biology news :

1. Understanding celiac disease
2. Understanding nutrition labels can lead to healthier eating
3. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
4. Salk news: Understanding organ placement
5. John Allen Paulos receives prestigious AAAS Award for Public Understanding of S&T
6. Understanding the impact of genetic technology
7. Salk news: Understanding gene function
8. Understanding obesity: New research examines how hunger signals work in the brain
9. From da Vinci to Monet: Understanding how artists can manipulate the human visual system
10. Understanding acetaminophen poisoning
11. Understanding our ape cousins: chimpanzee genetics may shed light on human diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... (PRWEB) , ... August 21, 2019 , ... ... E. coli cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, ... Formerly a member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than ...
(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures ... Food and Agriculture practice, a new unit dedicated to building 100 companies over the ... raw materials and supply chains. , Deep Science Ventures was founded to create ...
(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® ... they have opened a Customer Experience Center (CEC) and office in Munich, Germany. ... office. , The Munich CEC will be a place for researchers throughout Europe ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/8/2019)... (PRWEB) , ... September 04, 2019 , ... ... York Academy of Sciences announced today the three Winners and six Finalists ... postdoctoral scientists from academic research institutions across New York, New Jersey, and Connecticut ...
(Date:8/29/2019)... ... August 28, 2019 , ... DuPont Nutrition ... solutions to attendees at the International Baking Industry Expo, September 8 to 11, ... optimizing production efficiency to cost and waste reduction and from maintaining freshness throughout ...
(Date:8/23/2019)... ... 2019 , ... The EnozoPro® converts ordinary tap water into a sanitizing spray ... hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. It works as a ... the product page at rovingblue.com , ”At Enozo, our mission is to develop solutions ...
Breaking Biology Technology:
Cached News: