HOME >> BIOLOGY >> NEWS
Unique population of muscle stem cells found in mice

PITTSBURGH, May 21 Transplanting a unique population of muscle stem cells from healthy newborn mice delivers dystrophin, a key protein for muscle function, into mice born with a genetic muscle-wasting disease similar to Duchenne muscular dystrophy, Johnny Huard, Ph.D., and his colleagues report in the May 27 issue of the Journal of Cell Biology. The text is available online now at http://www.jcb.org.

Studying the behavior of these cells after transplant, we found some very exciting things, said Dr. Huard, who is an associate professor of orthopaedic surgery, molecular genetics, biochemistry and bioengineering at the University of Pittsburgh School of Medicine and director of the Growth and Development Laboratory at Childrens Hospital of Pittsburgh. Not only did the donor cells continue to grow and make dystrophin in the recipient, but they also apparently failed to provoke an immune response, which would protect them from rejection.

Dr. Huard, Zhuqing Qu-Peterson, Ph.D., and other colleagues from the University of Pittsburgh and the University of Bonn, Germany, isolated stem cells from the muscle of healthy newborn mice that had been grown in culture.

Using a technique called pre-plating, the dividing cells were culled into differing groups and eventually winnowed to what Dr. Huard calls muscle-derived stem cells or MDSC. These cells were injected into the muscles of mdx mice, a rodent model for Duchenne muscular dystrophy. In humans, this disease causes muscle weakness and early death because of respiratory or cardiac failure.

Dr. Huard and his colleagues are working on the transplantation of MDS cells as a potential approach to deliver dystrophin to the muscles of mdx mice. Less refined muscle cells, called EP (early plate) cells, also were transplanted into mdx mice for comparison.

These muscle-derived stem cells appear to be pluripotent; they can differentiate into muscle, neural and vascul
'"/>

Contact: Michele Baum
412-624-2607
University of Pittsburgh Medical Center
20-May-2002


Page: 1 2

Related biology news :

1. Unique partnership between UH, FDA opens path for scientific exchange
2. Unique two-part macroemulsion offers new approach to cleaning up contaminated aquifers
3. Unique fleet of underwater vehicles to gather elusive environmental data
4. Unique feeding behavior discovered for snakes
5. Unique social system found in famous Tsavo lions
6. Unique national park for orchids to be declared in Africa
7. Unique genetic alteration in presenilin 1 gene predisposes some Caribbean Hispanics to early-onset Alzheimers disease
8. Unique UNC study confirms suspected worldwide epidemic of childhood obesity
9. Scientists find just how discriminating a worm can be: Unique system of overlapping odor sensors discovered
10. Unique study reveals new details on how genes are transcribed
11. Unique international conference to focus on effectiveness, safety of medicinal herbs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2019)... ... 2019 , ... Advanced Clinical, a clinical research services organization, ... opening of new offices in Bucharest and Timisoara, Romania. Advanced Clinical’s increased interest ... in clinical trials. , Advanced Clinical’s entrance into Romania includes interdisciplinary teams ...
(Date:10/10/2019)... ... October 10, 2019 , ... Mindray, a global developer ... the American Society of Anesthesiologists 2019 Annual Meeting to visit exhibit #841 and ... Orlando, Florida, and will provide more than 14,000 healthcare professionals from around the ...
(Date:10/4/2019)... ... October 04, 2019 , ... Representatives with MyBioGate ( ... the Grand Elysée Hamburg Rothenbaumchaussee in Hamburg. , “To better connect Chinese companies ... Guo, Vice President of Operations and spokesperson for MyBioGate. , Guo went on ...
Breaking Biology News(10 mins):
(Date:9/30/2019)... ... September 30, 2019 , ... The September ... Rigaku Corporation , is now available online on the company’s global website. The ... including X-ray diffraction, fluorescence and imaging, and presents articles, scientific papers and news ...
(Date:9/24/2019)... ... September 24, 2019 , ... The Grain Foods Foundation ... Scientific Advisory Board. Dr. Holscher is an Assistant Professor of Nutrition in the ... at the University of Illinois Urbana-Champaign, where she has affiliate appointments with the ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell Consulting, an organization ... that its president and CEO Maryann Gallivan has been accepted into the Forbes ... Council accepted Gallivan based on the role she and Tunnell Consulting ...
Breaking Biology Technology:
Cached News: