HOME >> BIOLOGY >> NEWS
Unique population of muscle stem cells found in mice

PITTSBURGH, May 21 Transplanting a unique population of muscle stem cells from healthy newborn mice delivers dystrophin, a key protein for muscle function, into mice born with a genetic muscle-wasting disease similar to Duchenne muscular dystrophy, Johnny Huard, Ph.D., and his colleagues report in the May 27 issue of the Journal of Cell Biology. The text is available online now at http://www.jcb.org.

Studying the behavior of these cells after transplant, we found some very exciting things, said Dr. Huard, who is an associate professor of orthopaedic surgery, molecular genetics, biochemistry and bioengineering at the University of Pittsburgh School of Medicine and director of the Growth and Development Laboratory at Childrens Hospital of Pittsburgh. Not only did the donor cells continue to grow and make dystrophin in the recipient, but they also apparently failed to provoke an immune response, which would protect them from rejection.

Dr. Huard, Zhuqing Qu-Peterson, Ph.D., and other colleagues from the University of Pittsburgh and the University of Bonn, Germany, isolated stem cells from the muscle of healthy newborn mice that had been grown in culture.

Using a technique called pre-plating, the dividing cells were culled into differing groups and eventually winnowed to what Dr. Huard calls muscle-derived stem cells or MDSC. These cells were injected into the muscles of mdx mice, a rodent model for Duchenne muscular dystrophy. In humans, this disease causes muscle weakness and early death because of respiratory or cardiac failure.

Dr. Huard and his colleagues are working on the transplantation of MDS cells as a potential approach to deliver dystrophin to the muscles of mdx mice. Less refined muscle cells, called EP (early plate) cells, also were transplanted into mdx mice for comparison.

These muscle-derived stem cells appear to be pluripotent; they can differentiate into muscle, neural and vascul
'"/>

Contact: Michele Baum
412-624-2607
University of Pittsburgh Medical Center
20-May-2002


Page: 1 2

Related biology news :

1. Unique partnership between UH, FDA opens path for scientific exchange
2. Unique two-part macroemulsion offers new approach to cleaning up contaminated aquifers
3. Unique fleet of underwater vehicles to gather elusive environmental data
4. Unique feeding behavior discovered for snakes
5. Unique social system found in famous Tsavo lions
6. Unique national park for orchids to be declared in Africa
7. Unique genetic alteration in presenilin 1 gene predisposes some Caribbean Hispanics to early-onset Alzheimers disease
8. Unique UNC study confirms suspected worldwide epidemic of childhood obesity
9. Scientists find just how discriminating a worm can be: Unique system of overlapping odor sensors discovered
10. Unique study reveals new details on how genes are transcribed
11. Unique international conference to focus on effectiveness, safety of medicinal herbs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... San Diego, CA (PRWEB) , ... June 27, 2016 , ... ... mClinical solutions for clinical trials, announced today the Clinical Reach Virtual Patient ... and their care circle with the physician and clinical trial team. , Using the ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
Breaking Biology Technology:
Cached News: